Developmental profile of galanin binding sites in the Mammalian brain

Molecular and Cellular Neurosciences
J K ElmquistC D Jacobson

Abstract

Galanin (GAL) is a 29-amino acid peptide widely distributed in the mammalian nervous system. Recently, GAL expression has been shown to increase during periods of neuronal degeneration (e.g., Alzheimer's disease) and neuronal injury. Our laboratory has previously reported that GAL immunoreactivity (GAL-IR) is robustly expressed during a time of CNS plasticity, development. The striking GAL-IR seen during times of CNS morphogenesis and neurogenesis led us to the hypothesis that GAL may play a role in the formation of the nervous system. To further substantiate a developmental role for GAL we have used autoradiography to define the distribution of GAL receptors in the forming mammalian brain. To this end, we have used the Brazilian opossum, Monodelphis domestica, as a developmental model. In this study, we have described the profile of GAL receptors in the developing mammalian brain. [(125)I]GAL binding was detected as early as 1 day of postnatal life in regions of the brain which were still undergoing neurogenesis. High levels of GAL receptor expression were region specific and correlated with our previous results on GAL-IR during development. In addition, a transient binding pattern was seen in the anterior pituitary. In the ad...Continue Reading

Citations

Sep 11, 1998·The Journal of Comparative Neurology·M LandryT Hökfelt
Jan 8, 1999·Brain Research. Developmental Brain Research·J J SwansonC D Jacobson
Apr 18, 1995·Brain Research. Developmental Brain Research·J IqbalC D Jacobson
Sep 22, 1995·Regulatory Peptides·J N Crawley
Jun 8, 1994·The Journal of Comparative Neurology·J K ElmquistC D Jacobson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.