Developmental progress of CRISPR/Cas9 and its therapeutic applications for HIV-1 infection

Reviews in Medical Virology
Qiudi DengHuafeng Lin

Abstract

The CRISPR/Cas9 system has been developed as a powerful tool for targeted gene editing. As a result of technical enhancements in recent years, this technology has become the method of choice for efficiently modifying targeted HIV-1 genome efficiently as part of HIV therapy. CRISPR can be modified to target specific sequences that Cas9 then cuts. In this article, we outline the development of the CRISPR/Cas9 system. We also show how this technology can be used for the prevention and treatment of HIV-1 infection. Optimistically, this technology promises to make a significant impact on the fight against HIV-1 in the future.

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Citations

Oct 28, 2019·Current HIV Research·Maria João Almeida, Ana Matos
Jan 12, 2021·Frontiers in Cellular and Infection Microbiology·Amanda R PanfilKristine E Yoder
May 19, 2021·Orphanet Journal of Rare Diseases·Ana B Garcia-DelgadoBerta de la Cerda

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