Developmental regulation of calmodulin-dependent adenylate cyclase activity in an insect endocrine gland

Cell Regulation
V H MellerL I Gilbert

Abstract

The insect prothoracic gland produces ecdysteroids that elicit molting and metamorphosis, and neurohormone stimulation of steroidogenesis by this gland involves both Ca2+ and cyclic adenosine monophosphate second messengers. Prothoracic gland adenylate cyclase exhibits a complex Ca2+/calmodulin (CaM) dependence, a component of which requires an activated Gs alpha for expression. A developmental switch in this system has been identified that correlates with a change in both regulation and function of the gland and involves the loss of sensitivity to extracellular Ca2+ at a time approximately concurrent with the loss of Ca2+/CaM sensitivity by the adenylate cyclase. The extent of cholera toxin activation of gland Gs alpha is lowered before this developmental switch. However, no alterations in Gs alpha levels or mobility are detected, suggesting that Gs alpha interaction with another component in the signaling pathway, perhaps adenylate cyclase itself, produces the apparent Ca2+/CaM dependence and influences the ability of toxin to modify Gs alpha.

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·D Cassel, T Pfeuffer
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·K R WestcottD R Storm
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·F QuanM A Forte
Oct 6, 1989·JAMA : the Journal of the American Medical Association·A G Gilman
Sep 1, 1988·Molecular and Cellular Endocrinology·V H MellerL I Gilbert
Jan 1, 1985·Molecular and Cellular Endocrinology·W A SmithW E Bollenbacher
Jul 28, 1986·FEBS Letters·T AsanoM Sano
May 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L I GilbertD B Rountree
Jan 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S M MumbyA G Gilman
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S C TsaiM Vaughan
Jan 15, 1988·European Journal of Biochemistry·S Mollner, T Pfeuffer
Oct 1, 1984·Molecular and Cellular Endocrinology·W A SmithW E Bollenbacher
Jun 15, 1984·Science·W E BollenbacherA H Baumhover
Jul 15, 1980·Biochimica Et Biophysica Acta·M M JackowskiJ H Exton
Jul 1, 1981·General and Comparative Endocrinology·W E BollenbacherL I Gilbert

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Citations

Oct 23, 1998·Invertebrate Neuroscience : in·L I GilbertR Rybczynski
Dec 3, 1990·Molecular and Cellular Endocrinology·V H Meller, L I Gilbert
Nov 30, 1995·Molecular and Cellular Endocrinology·G C HayesR D Watson
Jan 1, 1993·Insect Biochemistry and Molecular Biology·M L GrieneisenL I Gilbert
Oct 6, 1999·Molecular and Cellular Endocrinology·S G Dedos, H Fugo
Mar 27, 2001·Insect Biochemistry and Molecular Biology·C H ChenY S Chow
Nov 14, 2002·Insect Biochemistry and Molecular Biology·Heiner Birkenbeil, Skarlatos G Dedos
Dec 1, 2001·Annual Review of Entomology·Lawrence I GilbertJames T Warren
Jan 10, 2006·Vitamins and Hormones·Edward M Berger, Edward B Dubrovsky

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