PMID: 9435635Jan 22, 1998Paper

Developmental regulation of erythropoietin and erythropoiesis

The American Journal of Physiology
K MoritzE M Wintour

Abstract

It is well established that erythropoiesis occurs first in the yolk sac, then in the liver, subsequently moving to the bone marrow and, in rodents, the spleen during development. The origin of the erythropoietic precursors and some factors suggested to be important for the changing location of erythropoiesis are discussed in this review. Until recently, the major site of erythropoietin (Epo) production in the fetus was thought to be the liver, but studies have shown now that the Epo gene is expressed strongly in the fetal kidney, even in the temporary mesonephros. The metanephric Epo mRNA is upregulated by anemia, downregulated by glucocorticoids, and contributes substantially to circulating hormone levels in hemorrhaged ovine fetuses. Other sites of Epo and Epo receptor production, likely to have important actions during development, are the placenta and the brain.

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Citations

May 15, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Joachim Fandrey
May 11, 2013·Current Heart Failure Reports·Jos WiddershovenNina Kupper
Jul 26, 2013·American Journal of Physiology. Renal Physiology·Yuki Sato, Motoko Yanagita
Sep 15, 2015·PloS One·Giuseppina Di GiacomoGabriele Gentile
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May 7, 2010·American Journal of Physiology. Renal Physiology·Volker H Haase
Jan 23, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Birgül Kurt, Armin Kurtz
Apr 27, 2011·The British Journal of Dermatology·T ItinteangD J Day
Apr 9, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andreas NordNeal J Dawson

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