Jan 1, 1981

Developmental regulation of glycoprotein biosynthesis in Dictyostelium

Journal of Supramolecular Structure and Cellular Biochemistry
R L IvattP W Robbins

Abstract

We have examined the glycoprotein-linked oligosaccharides assembled during the life cycle of Dictyostelium discoideum, and found their expression to be dramatically dependent upon the stage of development. During early development mature glycans have a high mannose character, and a substantial proportion acquire a fucose residue that correlates with endo-H resistance. One-third of the glycans also acquire sulfate residues. These glycans diminish in importance during aggregation. The mature glycans expressed during aggregation. The mature glycans expressed during late development contain fewer mannose residues, from five to ten mannose residues, and are characterized by the absence of sulfate residues and by the presence of fucose residues on endo-H-sensitive glycans. These glycans make their appearance coincident with the construction of tips on tight cell mounds. At this stage glycans characteristic of both early and late stages occur simultaneously. Developmental regulation of the wide array of protein-linked glycans expressed during the life cycle of Dictyostelium discoideum may be as simple as the controlled transition from a group of structures that are assembled by the vegetative cells to a group of structures that are as...Continue Reading

Mentioned in this Paper

Glycoproteins
Glycoprotein Biosynthetic Process
Aggregation
Cell Communication
Mannose
Cell Differentiation Process
Neoglycoproteins
Cell Adhesion
Cell Aggregation
Fucose

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