Developmental regulation of membrane excitability in rat spinal lamina I projection neurons.

Journal of Neurophysiology
Jie Li, Mark L Baccei

Abstract

It is now universally recognized that neonates can experience considerable pain. While spinal lamina I neurons projecting to the brain contribute to the generation of hyperalgesia, nothing is known about their electrophysiological properties during early life. Here we have used in vitro whole cell patch-clamp recordings in rat spinal cord slices to determine whether the intrinsic membrane properties of lamina I projection neurons, as well as their synaptic inputs, are developmentally regulated during the early postnatal period. Projection neurons were identified via retrograde transport of DiI injected into the parabrachial nucleus (PB) or periaqueductal gray (PAG) and characterized at postnatal days (P)2-5, P10-12, P19-23, and P30-32. Both spino-PB and spino-PAG neurons demonstrated an age-dependent reduction in spike threshold and duration at room temperature, which was accompanied by a developmental increase in the frequency of miniature excitatory and inhibitory postsynaptic currents. Notably, in both groups, age-dependent changes in the passive membrane properties or rheobase only occurred after the third postnatal week. However, spontaneous activity was significantly more prevalent within the developing spino-PB populatio...Continue Reading

References

Jul 1, 1985·Journal of Neuroscience Methods·E M Hoorneman
Jul 10, 1984·The Journal of Comparative Neurology·H R Bicknell, J A Beal
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·R A Baker, W J Shoemaker
Feb 8, 1993·The Journal of Comparative Neurology·K N NandiJ A Beal
May 17, 2002·The Journal of Physiology·Ruth Ruscheweyh, Jürgen Sandkühler
Nov 19, 2003·The European Journal of Neuroscience·R C SpikeA J Todd
Dec 25, 2003·The Journal of Physiology·Ruth RuscheweyhJürgen Sandkühler
May 21, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark L Baccei, Maria Fitzgerald
Apr 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yan Lu, Edward R Perl
May 10, 2005·The Journal of Physiology·Anne DahlhausJürgen Sandkühler
Aug 2, 2005·Neuroreport·Mark L Baccei, Maria Fitzgerald
Oct 21, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matilde Cordero-ErausquinYves De Koninck
Feb 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carole Torsney, Amy B MacDermott
Apr 7, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rebeccah SlaterMaria Fitzgerald
Jun 17, 2006·Science·Hiroshi IkedaJürgen Sandkühler
Dec 15, 2007·The Journal of Physiology·Lindsay R Bremner, Maria Fitzgerald
Feb 22, 2008·Journal of Neurophysiology·B A GrahamR J Callister
Jan 23, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claire A Daniele, Amy B MacDermott
Oct 14, 2009·The Journal of Comparative Neurology·Matilde Cordero-ErausquinYves De Koninck
May 28, 2010·The Journal of Comparative Neurology·Peter SzucsBoris V Safronov
Apr 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carole Torsney
Jun 17, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jie Li, Mark L Baccei

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Citations

Nov 8, 2014·The Journal of Comparative Neurology·Jie LiMark L Baccei
Aug 31, 2012·Journal of Neurophysiology·Alessandro RossiFederica Ginanneschi
Feb 11, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Mark L Baccei
Mar 6, 2021·Neuroscience Letters·Jie Li, Mark L Baccei

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