PMID: 9427510Jan 14, 1998Paper

Developmental regulation of Na+ / myo-inositol cotransporter gene expression

Brain Research. Molecular Brain Research
W GuoM Tohyama

Abstract

myo-Inositol plays a role in many important aspects of cellular regulation including membrane structure, signal transduction and osmoregulation. It is taken up into the cells by the Na+ / myo-inositol cotransporter (SMIT). We investigated developmental changes in the expression of SMIT mRNA and protein in the rat. In the fetal rat brain, SMIT mRNA was abundantly and diffusely expressed throughout the whole brain and the spinal cord. Positive signals were expressed in neuronal and non-neuronal cells in these regions. SMIT is gradually down-regulated nearer birth, but intense signals were still detected in the brain at postnatal day one. In the adult rat brain, very weak hybridization signals were detected throughout whole brain except for the choroid plexus where SMIT mRNA expression remained high. In contrast, the pattern of developmental regulation of SMIT gene expression in the kidney was opposite to that seen in the brain. Signals in the kidney were very weak during embryonic stages, whereas SMIT expression increased significantly after birth. These results suggest that myo-inositol and its transporter play an important role in the CNS developmental stage.

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Citations

Feb 13, 2001·Brain Research. Molecular Brain Research·T UedaS Shimada
Sep 5, 2001·Brain Research. Molecular Brain Research·T UedaS Shimada
Nov 1, 2001·Brain Research. Molecular Brain Research·A NishiwakiT Kato
Jan 16, 1999·Brain Research. Molecular Brain Research·N MizunoT Dohi
Oct 3, 2002·Journal of Neurochemistry·Stephen K FisherBernard W Agranoff
Mar 12, 2003·Neurologia Medico-chirurgica·Tomohiro KimuraSyoichi Shimada
Apr 22, 2009·Pediatric Neurology·Erika BrighinaMario Rango
Oct 25, 2012·Anatomy & Cell Biology·Jung-A ShinHwa-Young Lee
Sep 22, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jenny F L ChauStephen S M Chung
Jul 14, 2020·Frontiers in Physiology·Geoffrey W Abbott
Feb 13, 2003·The Journal of Biological Chemistry·Gerard T BerryJohn J Greer
Apr 6, 2000·American Journal of Physiology. Renal Physiology·A PavlovaS K Nigam
Apr 6, 2002·American Journal of Physiology. Renal Physiology·Djikolngar MaouyoHyug M Kwon
Sep 17, 2009·Biochemical Society Transactions·Elena Di DanielPeter R Maycox
Dec 8, 2020·Critical Reviews in Food Science and Nutrition·Oliver C WatkinsShiao-Yng Chan
Nov 6, 2018·Developmental Neuroscience·Xing-Liang YangBi-Wen Peng

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