Developmental regulation of production of an aggregation-stimulating factor from the cellular slime mold Polysphondylium violaceum

Differentiation; Research in Biological Diversity
M H HannaF Arnal

Abstract

An excreted, dialyzable component(s) produced during development of wild-type Polysphondylium violaceum has been previously shown to stimulate aggregation of aggregateless mutants in the complementation group aggA. Production of this aggregation-stimulating factor, called D factor, is greater during development in liquid culture than during development on a surface. after partial purification of crude D factor using high performance liquid chromatography, multiple species are found that retain the ability to stimulate aggregation of the aggA mutants. The three major components (DfA, DfB, and DfC) show decreasing polarity based on purification using reverse-phase chromatography. The proportion of each component secreted varies, depending on the developmental conditions (surface versus liquid) and the time after starvation when the factors are isolated. Preliminary physical and chemical characterization of the three D factor components suggests that they are related.

References

Mar 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B WursterJ T Bonner
Nov 14, 1969·Science·A W Barksdale
Oct 1, 1968·Journal of Bacteriology·H van den Ende
Jul 1, 1966·Biochemistry·L MachlisH Rapoport
Jul 8, 1967·Nature·H van den Ende
Jul 15, 1967·Nature·T C McMorris, A W Barksdale
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·O ShimomuraJ T Bonner

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