Developmental regulation of the lung in preparation for life after birth: hormonal and nutritional manipulation of local glucocorticoid action and uncoupling protein-2

The Journal of Endocrinology
M G GnanalinghamM E Symonds

Abstract

Glucocorticoid action has a major role in regulating fetal and postnatal lung development, although its impact on mitochondrial development is less well understood. Critically, the consequences of any change in glucocorticoid action and mitochondrial function in early life may not be limited to the postnatal period, but may extend into later life. This paper focuses on more recent findings on the impact of ontogeny, fetal cortisol status, maternal nutrient restriction and postnatal leptin administration on mitochondrial uncoupling protein (UCP)-2, glucocorticoid receptor (GR) and 11 beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) isoform abundance in the lung. For example, in sheep, GR and 11betaHSD1 mRNA are maximal at 140 days' gestation (term approximately 147 days), while UCP2 mRNA peaks at 1 day after birth and then decreases with advancing age. In the fetus, chronic umbilical cord compression enhances the abundance of these genes, an outcome that can also be produced after birth following chronic, but not acute, leptin administration. Irrespective of the timing of maternal nutrient restriction in pregnancy, glucocorticoid sensitivity and UCP2 abundance are both upregulated in the lungs of the resulting offspring. In...Continue Reading

Citations

Aug 17, 2011·Journal of Epidemiology and Community Health·Swatee P PatelMarjo-Riitta Järvelin
Nov 3, 2010·Respiratory Research·Foteini MalliZoe Daniil
Nov 2, 2013·American Journal of Respiratory and Critical Care Medicine·Alvar AgustíPeter K Jeffery
Nov 29, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·D P YakubuM E Symonds
Jan 19, 2010·Biological Psychology·Rosalind J Wright
May 27, 2015·Annals of the American Thoracic Society·Yeon-Mok OhUNKNOWN KOLD Study Group
Mar 30, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Pierre R ProvostYves Tremblay
Jan 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie A HyattMichael E Symonds
May 18, 2021·Frontiers in Cell and Developmental Biology·Yu XuefeiFu Jianhua

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