PMID: 7529304Aug 1, 1994Paper

Developmental regulation of the porcine exocrine pancreas by glucocorticoids

Journal of Pediatric Gastroenterology and Nutrition
P T SangildM Silver

Abstract

The possible role of cortisol in development of the exocrine pancreas was investigated. In the first study, fetal pigs were removed from the uterus by caesarean section (pentobarbitone anesthesia) and the pancreas collected from 51 69 to 109-day-old fetuses (term = 114 +/- 2 days). Of these, 15 88 to 90-day-old fetuses had been infused subcutaneously for 6 days with either saline, adrenocorticotropic hormone or cortisol (osmotic mini-pumps implanted at 82-84 days). The pancreas was also removed from eight newborn pigs. Quantitative enzyme analysis showed that amylase and trypsin activities per milligram pancreatic protein increased toward term, correlated positively with fetal plasma cortisol (p < 0.01) and were stimulated by cortisol infusion (p < 0.05). In the second study, pigs were delivered by caesarean section 2-3 days before term (to circumvent the neonatal cortisol surge) and injected intramuscularly with saline (n = 11), metyrapone (an inhibitor of cortisol synthesis, n = 12), adrenocorticotropic hormone (n = 14) or cortisol acetate (n = 6) during the postnatal period. At 6-7 days of age, adrenocorticotropic hormone- and cortisol acetate-treated pigs had higher concentrations of amylase and trypsin in pancreas than met...Continue Reading

Citations

Sep 1, 1996·Comparative Biochemistry and Physiology. Part A, Physiology·J Elnif, P T Sangild
Oct 5, 2001·Domestic Animal Endocrinology·J A Carroll
Jul 27, 2002·Domestic Animal Endocrinology·R RenavilleD Portetelle
Nov 26, 1998·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J N Mubiru, R J Xu
Oct 30, 2012·General and Comparative Endocrinology·Dinushan Nesan, Mathilakath M Vijayan
Oct 22, 2008·Advances in Medical Sciences·J Morisset
Jan 10, 2002·Seminars in Perinatology·P G Brosnan
May 21, 2003·American Journal of Veterinary Research·Randal K BuddingtonJillian B Donahoo
Sep 28, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Per T SangildRandal K Buddington
Mar 13, 2015·Molecular Endocrinology·Melanie E PefferDonald B DeFranco
Feb 13, 2013·Journal of Animal Science·R K BuddingtonD D Black
Jun 1, 1997·Equine Veterinary Journal. Supplement·J F Trahair, P T Sangild
May 8, 1998·The Proceedings of the Nutrition Society·A L FowdenA J Forhead
Dec 2, 2006·Experimental Biology and Medicine·Per T Sangild
Aug 15, 2013·Journal of Animal Science·P T SangildR K Buddington
Sep 11, 2002·The Journal of Nutrition·Per T SangildDouglas G Burrin
Dec 21, 2002·The Journal of Nutrition·Per T SangildDouglas G Burrin
Jul 13, 2021·Frontiers in Nutrition·Ester Arévalo SuredaThomas Thymann

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