Oct 1, 1989

Developmental regulation of the rat insulin-like growth factor I receptor gene

Proceedings of the National Academy of Sciences of the United States of America
H WernerD LeRoith

Abstract

We have investigated the developmental regulation of the rat insulin-like growth factor I (IGF-I) receptor gene in various tissues using a sensitive and specific solution hybridization/RNase protection assay. For this purpose we characterized rat IGF-I receptor cDNAs that were cloned from a simian virus 40-transformed rat granulosa cell cDNA library. The specific cDNA clone used in these studies encoded the putative signal peptide and the first 53 amino acids of the alpha subunit and was approximately 94% homologous to its human counterpart. IGF-I receptor gene expression was studied during the perinatal period and at various intervals until early adulthood. Overall, steady-state IGF-I receptor mRNA levels decreased dramatically during postnatal development; however, the extent of the decrease differed among the various tissues studied. In contrast to receptor mRNA levels, IGF-I mRNA levels increased in some of the same tissues. The molecular mechanisms underlying this apparent divergent transcriptional control of the IGF-I and IGF-I receptor genes warrant further study.

Mentioned in this Paper

Granulosa Cell
Insulin-Like Growth Factor I
Transcriptional Regulation
Adenine Polynucleotides
Hormone Receptors, Cell Surface
Amino Acids, I.V. solution additive
August Rats
Insulin-Like-Growth Factor I Receptor
Brain
Simian virus 40

About this Paper

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