Developmental regulation of vascular endothelial growth/permeability factor messenger ribonucleic acid levels in and vascularization of the villous placenta during baboon pregnancy

Endocrinology
V A HildebrandtE D Albrecht

Abstract

Vascular endothelial growth/permeability factor (VEG/PF) has an important role in angiogenesis; however, very little is known about the developmental regulation of VEG/PF and the vascular system within the placenta during human pregnancy. In the present study, therefore, a developmental approach was used in the baboon to determine the placental source of VEG/PF and its fms-like tyrosine kinase (flt-1) and kinase-insert domain containing (KDR/flk-1) receptors, and whether the rise in estrogen with advancing pregnancy was associated with a corresponding increase in placental VEG/PF expression and vascularization. VEG/PF messenger RNA (mRNA) levels were determined by competitive RT-PCR in villous cell fractions isolated by Percoll gradient centrifugation from placentas obtained on days 45 and 54 (very early), 60 (early), 100 (mid), and 165-170 (late) of baboon pregnancy (term = 184 days). Maternal peripheral serum estradiol increased from very low concentrations early in gestation (0.15-0.20 ng/ml) to an early surge of over 2.5 ng/ml on days 60-85, and peak levels of 4-6 ng/ml late in baboon pregnancy. VEG/PF mRNA was expressed in low level in the syncytiotrophoblast (<2,000 attomol/microgram total RNA), and values in this fractio...Continue Reading

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Citations

Jan 29, 2010·Biology of Reproduction·Kathrin A DunlapKayla J Bayless
Mar 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Graham W AberdeenEugene D Albrecht
Oct 31, 2009·The International Journal of Developmental Biology·Eugene D Albrecht, Gerald J Pepe
Feb 22, 2002·Biochemical and Biophysical Research Communications·Sachiko YamaguchiMasabumi Shibuya
Dec 18, 2002·International Journal of Experimental Pathology·Lawrence P ReynoldsDale A Redmer
Apr 2, 2014·Mayo Clinic Proceedings·Elizabeth Ann L EnningaSvetomir N Markovic
May 14, 2016·Theriogenology·S BairagiL P Reynolds
Jan 7, 2004·Journal of the Society for Gynecologic Investigation·D W BurleighT G Golos
Oct 6, 2007·The Journal of Veterinary Medical Science·Phil-Ok KohMyeong-Ok Kim
Nov 21, 2007·Molecular Reproduction and Development·Eugene D AlbrechtGerald J Pepe

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