PMID: 8939716Oct 1, 1996Paper

Developmental regulation of V(D)J recombination and lymphocyte differentiation

Current Opinion in Genetics & Development
D M WillerfordF W Alt

Abstract

Recent insights into the mechanism of V(D)J recombination have clarified the direct role of the products of the recombination-activating genes Rag-1 and Rag-2 in site-specific DNA cleavage at recombination signal sequences and have identified components of the general DNA double-strand break repair pathway that participate in the rejoining of the Rag-1 and Rag-2-cut receptor gene segments. The V(D)J reaction is restricted to particular antigen receptor loci in a lineage-specific and stage-specific manner. This specificity appears to involve cis-regulatory elements, some of which also regulate transcription of the germline antigen receptor loci. Early developmental steps in the T and B lineages - including phenotypic differentiation, expansion of precursors, and selection processes - are effected in a stepwise fashion by signals generated, at least in part, by the products of the functionally rearranged antigen receptor genes themselves.

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Citations

Nov 13, 2002·Mutation Research·Mark O'Driscoll, Penny Jeggo
May 29, 1998·Current Opinion in Immunology·H Clevers, P Ferrier
Jan 26, 2002·Journal of Photochemistry and Photobiology. B, Biology·P A Jeggo, P Concannon
Jan 2, 2003·DNA Repair·Penny Jeggo, Peter O'Neill
Jul 12, 2011·Nature Genetics·Simon L GirardGuy A Rouleau
Jun 24, 1998·The Journal of Experimental Medicine·J P ManisF W Alt
Aug 26, 1998·The Journal of Experimental Medicine·E MeffreM C Nussenzweig
Oct 23, 1998·The Journal of Experimental Medicine·B P SleckmanF W Alt
Mar 12, 2003·The Journal of Experimental Medicine·Nandita SinghAndrew Chess
May 16, 2007·The Journal of Experimental Medicine·Ching-Yu HuangBarry P Sleckman
Mar 10, 2001·Cold Spring Harbor Symposia on Quantitative Biology·J M SekiguchiF W Alt
Dec 16, 1998·Immunological Reviews·B P SleckmanF W Alt
May 29, 1998·Immunological Reviews·N S GreenM D Scharff
May 29, 2000·Molecular and Cellular Biology·B P SleckmanF W Alt
Jan 2, 2003·Molecular and Cellular Biology·Susan M MendrysaMary Ellen Perry
Dec 9, 2009·Annual Review of Immunology·Max D Cooper
Jun 8, 1999·Annual Review of Immunology·J L ClementsG A Koretzky
Jun 22, 1999·The Journal of Clinical Investigation·G J VanasseD M Willerford
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·A C ShawF W Alt
Jul 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·S R CherryD Baltimore
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·R J MonroeF W Alt
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y GuF W Alt
Sep 15, 1999·Proceedings of the National Academy of Sciences of the United States of America·S R Cherry, D Baltimore
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Craig H BassingFrederick W Alt
Aug 23, 2002·Immunological Reviews·Max D Cooper
Jul 9, 2003·Immunological Reviews·Kevin D MillsFrederick W Alt
Dec 16, 2000·Expert Opinion on Investigational Drugs·F Mastrandrea
Aug 28, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Makoto Otsu, Fabio Candotti
Apr 20, 2002·Blood·Peter I ChuangDennis M Willerford
Feb 6, 2016·Oncotarget·Seung Eun LeeYoung Hyeh Ko
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L D ShultzD L Greiner
Oct 22, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Denise A MartinGillian E Wu

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