PMID: 9191974Feb 1, 1997Paper

Developmental response by Leydig cells to acidic and basic fibroblast growth factor

The Journal of Steroid Biochemistry and Molecular Biology
A LaslettG P Risbridger

Abstract

The present study examines the effects of acidic (FGF-1) and basic (FGF-2) fibroblast growth factors on Leydig cell steroidogenesis by cells from 5-, 21- and 90-day-old rats. These ages represent three distinct time points in Leydig cell development: fetal Leydig cells (day 5), immature Leydig cells (day 21) and adult Leydig cells (day 90). The results demonstrate that the actions of the two growth factors on steroidogenesis are developmentally regulated, and require the presence of heparan sulphate proteoglycans (HSPG). FGF-1 and FGF-2 both had stimulatory effects on basal, but not maximally LH-stimulated, testosterone production by fetal Leydig cells, and both growth factors stimulated basal 5 alpha-androstane-3 alpha, 17 beta-diol production by immature Leydig cells. These effects were mediated by heparan sulphate-proteoglycans (HSPG), as they were blocked by the addition of protamine sulphate and sodium chlorate. FGF-1 and FGF-2 had no effect on basal testosterone production by adult Leydig cells, however, FGF-1 alone inhibited LH-stimulated testosterone production by adult Leydig cells in a dose-dependent manner. These data demonstrate that the effects of FGF-1 and FGF-2 are dependent on the specific stage of Leydig cell d...Continue Reading

References

Nov 1, 1992·Proceedings of the Society for Experimental Biology and Medicine·I Huhtaniemi, L J Pelliniemi
Jan 2, 1990·Molecular and Cellular Endocrinology·E P Murono, A L Washburn
Apr 16, 1990·Biochemical and Biophysical Research Communications·E P Murono, A L Washburn
Apr 1, 1989·Cell and Tissue Research·T Kuopio, L J Pelliniemi
Jun 1, 1989·Differentiation; Research in Biological Diversity·T KuopioL J Pelliniemi
Oct 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K HayashiM Bernfield
Aug 1, 1988·Molecular and Cellular Endocrinology·C SordoilletM Benahmed
Feb 29, 1988·Biochemical and Biophysical Research Communications·J I RaesideJ M Saez
Feb 1, 1987·Molecular and Cellular Endocrinology·N UenoR Guillemin
Nov 1, 1993·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R de Iongh, J W McAvoy
Jun 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·L BentonM P Hardy
Apr 19, 1996·Molecular and Cellular Endocrinology·J R McFarlaneG P Risbridger

❮ Previous
Next ❯

Citations

Jun 16, 1999·The Journal of Steroid Biochemistry and Molecular Biology·N GrudetS Carreau
Aug 9, 2012·The Journal of Endocrinology·N B SchreiberL J Spicer
Sep 28, 2014·Molecular and Cellular Endocrinology·S B WingeE Rajpert-De Meyts
Jun 11, 2009·International Journal of Andrology·Yung Ming LinBu Miin Huang
Oct 26, 2013·Journal of Diabetes Research·Xin JiangYaqin Qu
Jan 21, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Irma G Gonzalez-HerreraAnne-Catherine Prats
Dec 4, 2019·Zygote : the Biology of Gametes and Early Embryos·Chunjie LiJing Wang
Mar 25, 2019·Frontiers in Endocrinology·Lanlan ChenRen-Shan Ge

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.