Developmental responses to high-altitude hypoxia in Bolivian children of European ancestry: A test of the developmental adaptation hypothesis

American Journal of Human Biology : the Official Journal of the Human Biology Council
L P Greksa

Abstract

The developmental adaptation hypothesis (DAH) proposes that highlanders adapt to their hypobaric hypoxic environment during growth and development. This report utilizes data on children (9.0-19.9 yr) of European ancestry residing in Santa Cruz and La Paz, Bolivia, to test selected aspects of the DAH. Previous tests of this hypothesis have been hampered by difficulties in controlling for socioeconomic and genetic influences. However, due to their high socioeconomic status and their relatively short history of residence at high altitudes, these factors can be reasonably well controlled in studies of European children. The data on European children are consistent with some but not all aspects of the DAH. First, examination of the available data on V̇O2 max (ml/kg/min) in European boys suggests that chronic exposure to hypobaric hypoxia results in an enhancement of the overall functional capacity of the oxygen transport system during adolescence, as predicted by the DAH. Second, chronic exposure to hypobaric hypoxia results in a delay in linear growth and maturation in European children, as well as in an enhancement of their lung volumes, also as predicted by the DAH. However, the effects of chronic hypoxia on linear growth, after ...Continue Reading

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Citations

Jun 24, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Charles A Weitz, Ralph M Garruto
Sep 16, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Alison M McManusMaurice P Leung
Mar 7, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Robert Walker, Kim Hill
Sep 16, 2018·International Journal of Biometeorology·Snigdha ShawBhuvnesh Kumar
May 16, 2007·American Journal of Physical Anthropology·Karen J Weinstein
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·Robert F Grover
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Apr 30, 2021·American Journal of Physical Anthropology·Stephanie B LevyWilliam R Leonard
Jun 25, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Feng ZhangMing Li

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