Abstract
The developmental adaptation hypothesis (DAH) proposes that highlanders adapt to their hypobaric hypoxic environment during growth and development. This report utilizes data on children (9.0-19.9 yr) of European ancestry residing in Santa Cruz and La Paz, Bolivia, to test selected aspects of the DAH. Previous tests of this hypothesis have been hampered by difficulties in controlling for socioeconomic and genetic influences. However, due to their high socioeconomic status and their relatively short history of residence at high altitudes, these factors can be reasonably well controlled in studies of European children. The data on European children are consistent with some but not all aspects of the DAH. First, examination of the available data on V̇O2 max (ml/kg/min) in European boys suggests that chronic exposure to hypobaric hypoxia results in an enhancement of the overall functional capacity of the oxygen transport system during adolescence, as predicted by the DAH. Second, chronic exposure to hypobaric hypoxia results in a delay in linear growth and maturation in European children, as well as in an enhancement of their lung volumes, also as predicted by the DAH. However, the effects of chronic hypoxia on linear growth, after ...Continue Reading
References
Aug 27, 1976·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·I G Pawson
Jul 1, 1979·The Journal of Pediatrics·K H HsuG S Hsieh
Jul 1, 1978·Annals of Human Biology·W H MuellerF Rothhammer
May 13, 1976·Nature·S LahiriC Polgar
Jan 1, 1990·Annals of Human Biology·L P Greksa
Nov 1, 1989·American Journal of Physical Anthropology·W R Leonard
Jan 1, 1988·American Journal of Physical Anthropology·L P GreksaL Paredes-Fernández
Apr 1, 1988·Journal of Applied Physiology·N FellmannJ Coudert
Nov 1, 1987·Annals of Human Biology·L P GreksaL Paredes-Fernández
Jan 1, 1986·Journal of Applied Physiology·N FellmannJ Coudert
May 1, 1985·Annals of Human Biology·L P GreksaE Caceres
Jul 1, 1985·American Journal of Physical Anthropology·L P GreksaL Paredes-Fernández
Apr 6, 1974·Lancet·J P HabichtR E Klein
Apr 1, 1974·Annals of Human Biology·A J BoyceG A Harrison
Feb 1, 1973·Journal of Applied Physiology·A R FrisanchoH Montoye
Mar 1, 1970·American Journal of Physical Anthropology·A R Frisancho, P T Baker
Nov 1, 1984·American Journal of Physical Anthropology·L P GreksaE Caceres
Jun 1, 1983·American Journal of Physical Anthropology·J E SchutteR L Johnson
Mar 1, 1981·International Journal of Radiation Oncology, Biology, Physics·I A BrezovichD B Richards
Sep 1, 1982·American Journal of Physical Anthropology·S Stinson
Nov 1, 1982·American Journal of Physical Anthropology·J D HaasL Hurtado
Sep 1, 1980·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·P H HackettD Rennie
Oct 1, 1980·The Journal of Pediatrics·L M TaussigR B Mellins
Citations
Jun 24, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Charles A Weitz, Ralph M Garruto
Sep 16, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Alison M McManusMaurice P Leung
Mar 7, 2003·American Journal of Human Biology : the Official Journal of the Human Biology Council·Robert Walker, Kim Hill
Sep 16, 2018·International Journal of Biometeorology·Snigdha ShawBhuvnesh Kumar
May 16, 2007·American Journal of Physical Anthropology·Karen J Weinstein
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·Robert F Grover
Jan 1, 1993·American Journal of Human Biology : the Official Journal of the Human Biology Council·S Williams-BlangeroC M Beall
Jan 1, 1994·American Journal of Human Biology : the Official Journal of the Human Biology Council·P T KatzmarzykR I Sukernik
Jan 1, 1994·American Journal of Human Biology : the Official Journal of the Human Biology Council·Gustavo F Gonzales, Ivan Ortiz
Jan 5, 2000·American Journal of Physical Anthropology·C A WeitzX He
Sep 1, 1995·American Journal of Physical Anthropology·W R LeonardM K McCaston
Dec 1, 1995·American Journal of Physical Anthropology·D A MerriwetherR E Ferrell
Aug 1, 1994·American Journal of Physical Anthropology·L P GreksaE Caceres
Jun 1, 1997·Biulleten' eksperimental'noĭ biologii i meditsiny·E V OrlovaV K Gabitov
Aug 16, 2018·Royal Society Open Science·Stephanie PayneJay Stock
Dec 6, 2018·American Journal of Speech-language Pathology·Shelly Jo KraftJanet Beilby
Sep 5, 2001·American Journal of Human Biology : the Official Journal of the Human Biology Council·Charles A. WeitzXing He
Aug 29, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I GrantD A Giussani
Jul 12, 2002·American Journal of Human Biology : the Official Journal of the Human Biology Council·Charles A WeitzXing He
May 4, 2012·American Journal of Physical Anthropology·Melisa KiyamuTom D Brutsaert
Nov 12, 2014·American Journal of Physical Anthropology·Melisa KiyamuTom D Brutsaert
Sep 27, 2015·American Journal of Physical Anthropology·Charles A WeitzChen-Ting Chin
May 16, 2015·High Altitude Medicine & Biology·Melisa KiyamuTom D Brutsaert
Jan 26, 2013·American Journal of Human Biology : the Official Journal of the Human Biology Council·Cynthia M Beall
Jun 13, 2006·High Altitude Medicine & Biology·Lawrence P Greksa
Apr 30, 2021·American Journal of Physical Anthropology·Stephanie B LevyWilliam R Leonard
Jun 25, 2021·American Journal of Human Biology : the Official Journal of the Human Biology Council·Feng ZhangMing Li