Developmental reversal in neuropeptide Y action on feeding in an amphibian

General and Comparative Endocrinology
E J Crespi, R J Denver

Abstract

Neuropeptide Y (NPY) is expressed in the hypothalamus where it exerts orexigenic actions within the feeding control circuit. While NPY stimulates feeding in juvenile and adult animals, it is not known whether NPY influences food intake at earlier life stages. We investigated a role for NPY in regulating feeding at two stages of the life cycle of an amphibian, the Western spadefoot toad Spea hammondii. We administered NPY by intracerebroventricular (i.c.v.) injection to juvenile toads or prometamorphic tadpoles, and monitored locomotion, feeding behavior and/or food intake. Injection of NPY (20 or 200 ng/g BW) into juvenile toads decreased the latency to, and increased the number of strikes at prey, and the number of crickets eaten compared to uninjected or vehicle-injected controls. By contrast, injection of NPY (0.02-20 ng/g BW) into prometamorphic tadpoles caused a dose-dependent decrease in time spent foraging compared to controls. Blocking NPY signaling in the prometamorphic tadpole brain by i.c.v. injection of a general NPY receptor antagonist increased foraging, and partly blocked the action of exogenous NPY on foraging. Taken together, our findings show a developmental reversal in NPY actions on feeding in an amphibian, ...Continue Reading

References

Jan 22, 1993·The Journal of Comparative Neurology·G LázárI Merchenthaler
Mar 9, 1999·European Journal of Endocrinology·R KrysiakZ S Herman
Sep 21, 2001·Physiology & Behavior·Y K Narnaware, R E Peter
Aug 6, 2002·General and Comparative Endocrinology·Karen Ann Glennemeier, Robert John Denver
Jun 24, 2003·Physiology & Behavior·Kevin L Grove, M Susan Smith
Jun 11, 2004·Journal of Neuroendocrinology·B S MühlhäuslerC L Adam
Feb 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Diane E DayTimothy J Bartness
Jun 29, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Weidong ZhouKunio Sugahara
Sep 6, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Erica J Crespi, Robert J Denver
Dec 6, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hélène Volkoff
Jun 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Erica J Crespi, Robert J Denver
Feb 6, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Megan J Dailey, Timothy J Bartness
Jul 12, 2011·Evolution & Development·Cris C Ledón-Rettig, David W Pfennig

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