Developmental robustness by obligate interaction of class B floral homeotic genes and proteins.

PLoS Computational Biology
Thorsten LenserPeter Dittrich

Abstract

DEF-like and GLO-like class B floral homeotic genes encode closely related MADS-domain transcription factors that act as developmental switches involved in specifying the identity of petals and stamens during flower development. Class B gene function requires transcriptional upregulation by an autoregulatory loop that depends on obligate heterodimerization of DEF-like and GLO-like proteins. Because switch-like behavior of gene expression can be displayed by single genes already, the functional relevance of this complex circuitry has remained enigmatic. On the basis of a stochastic in silico model of class B gene and protein interactions, we suggest that obligate heterodimerization of class B floral homeotic proteins is not simply the result of neutral drift but enhanced the robustness of cell-fate organ identity decisions in the presence of stochastic noise. This finding strongly corroborates the view that the appearance of this regulatory mechanism during angiosperm phylogeny led to a canalization of flower development and evolution.

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Citations

Jul 24, 2010·BMC Systems Biology·Simon van MourikJaap Molenaar
Oct 29, 2010·BMC Genomics·Aalt D J van Dijk, Roeland C H J van Ham
Jun 20, 2012·The Plant Journal : for Cell and Molecular Biology·María Manchado-RojoMarcos Egea-Cortines
Dec 17, 2009·The Plant Journal : for Cell and Molecular Biology·Rongfeng CuiZheng Meng
Feb 26, 2016·Molecular Biology and Evolution·Madelaine BartlettClinton Whipple
Nov 4, 2009·Seminars in Cell & Developmental Biology·Richard G H ImminkGerco C Angenent
Sep 25, 2014·Molecular BioSystems·Katrin BohlAnja Schroeter
Sep 6, 2017·Scientific Reports·Rómulo Sobral, M Manuela R Costa
Nov 11, 2010·Nature Reviews. Genetics·Kerstin KaufmannGerco C Angenent
Mar 29, 2011·Annals of Botany·K GeutenV F Irish
Apr 10, 2018·Frontiers in Plant Science·Kelsey D GalimbaVerónica S Di Stilio
Aug 29, 2021·Plants·Ana Teresa AlhinhoMaria Manuela Ribeiro Costa
Nov 20, 2009·Seminars in Cell & Developmental Biology·Elena R Alvarez-BuyllaPablo Padilla-Longoria

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Methods Mentioned

BETA
transgenic
two-hybrid

Software Mentioned

MATLAB

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