Abstract
Although PTHrP is produced in multiple fetal tissues, its precise physiological functions have yet to be clearly elucidated. The present study was undertaken to elucidate the biological role of PTHrP in the development of tooth. In rat tooth germs, the PTHrP and its receptor genes were expressed in the enamel organ and dental mesenchyme, respectively. When mouse tooth explants were cultured with antisense oligodeoxyribonucleotides (ODN) against mouse PTHrP mRNA in serum-free medium, an invasion of bone tissue was observed in the tooth germs. On the other hand, the explants cultured without ODN or with sense ODN showed normal histological structures similar to those observed in vivo. These results suggest that PTHrP is essential for tooth development and for the protection of tooth germs from the invasion of bone tissue.
Citations
Feb 27, 2004·Journal of Human Evolution·Julia C Boughner, M Christopher Dean
Jan 17, 2002·Bone·Y KitaharaY Takano
Jun 15, 2007·Archives of Histology and Cytology·Atsushi MiyataYoshiro Takano
Jul 8, 2015·Cell and Tissue Research·Haiyan SunCheng Ge
Nov 16, 2004·Bone·Y KitaharaK Ohyama
Apr 28, 2004·Mechanisms of Development·L M CalviE Schipani
Jul 25, 2000·Mechanisms of Development·J G LiuK Kurisu
Nov 19, 2015·PLoS Genetics·Maria VoutilainenMarja L Mikkola
Sep 6, 2000·Archives of Oral Biology·G E WiseS J Lumpkin
Sep 24, 2002·Archives of Oral Biology·Kongkwan MekaapirukTatsuo Terashima
Dec 5, 2013·Journal of Dental Research·S A Frazier-BowersS Bencharit
Jul 23, 2005·Toxicologic Pathology·Atsuhiko KatoKunio Doi
May 21, 2005·Toxicologic Pathology·Atsuhiko KatoKunio Doi
Oct 2, 2004·European Journal of Oral Sciences·G E WiseS Yao
Sep 30, 2005·Journal of Anatomy·Yasunori SakakuraToshihiko Yajima
Jun 26, 2020·Journal of Dental Research·C CuiY Fan
Feb 10, 2016·Endocrinology·Wen SunDengshun Miao
Aug 31, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hiroko Ida-Yonemochi, Takashi Saku
May 6, 2021·Nature Reviews. Endocrinology·Christopher S KovacsRajesh V Thakker