PMID: 9541217Apr 16, 1998Paper

Developmental role of PTHrP in murine molars

European Journal of Oral Sciences
J G LiuK Kurisu

Abstract

Although PTHrP is produced in multiple fetal tissues, its precise physiological functions have yet to be clearly elucidated. The present study was undertaken to elucidate the biological role of PTHrP in the development of tooth. In rat tooth germs, the PTHrP and its receptor genes were expressed in the enamel organ and dental mesenchyme, respectively. When mouse tooth explants were cultured with antisense oligodeoxyribonucleotides (ODN) against mouse PTHrP mRNA in serum-free medium, an invasion of bone tissue was observed in the tooth germs. On the other hand, the explants cultured without ODN or with sense ODN showed normal histological structures similar to those observed in vivo. These results suggest that PTHrP is essential for tooth development and for the protection of tooth germs from the invasion of bone tissue.

Citations

Jun 15, 2007·Archives of Histology and Cytology·Atsushi MiyataYoshiro Takano
Nov 19, 2015·PLoS Genetics·Maria VoutilainenMarja L Mikkola
Dec 5, 2013·Journal of Dental Research·S A Frazier-BowersS Bencharit
May 21, 2005·Toxicologic Pathology·Atsuhiko KatoKunio Doi
Oct 2, 2004·European Journal of Oral Sciences·G E WiseS Yao
Jun 26, 2020·Journal of Dental Research·C CuiY Fan
Aug 31, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Hiroko Ida-Yonemochi, Takashi Saku
May 6, 2021·Nature Reviews. Endocrinology·Christopher S KovacsRajesh V Thakker

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