PMID: 7370737Apr 14, 1980Paper

Developmental studies of the uptake of choline, GABA and dopamine by crude synaptosomal preparations after in vivo or in vitro lead treatment

Brain Research
P B RamsayP Morell

Abstract

The kinetics of sodium dependent, high affinity uptake of choline and dopamine by striatal synaptosomal preparations and of GABA (gamma-aminobutyric acid) by cortical synaptosomal preparations have been examined during the development of Long-Evans control and lead-treated rats. Choline uptake was very low until 12 days postnatally, then the Vmax increased and approached adult values of 29 pmol/mg prot./min within a week. GABA uptake was somewhat elevated at birth and only after three weeks did it decrease to the adult value of 0.7 nmol/mg prot./min. Dopamine uptake was low at birth, developed linearly with age and by 30 days postnatally approached the adult value of 68 pmoles/mg prot./min. The high affinity uptake constants (choline, 0.66 microM; GABA, 4.4 muM; and dopamine, 0.31 muM) did not change markedly during development. Similar studies were conducted with rats treated at the highest lead dosage which did not result in weight loss (100 microgram lead as lead acetate/g body weight/day via intubation). Blood and brain lead determinations confirmed a substantial lead exposure. Such chronic exposure did not markedly affect the amount or developmental pattern of uptake of the putative neurotransmitters. The effect of 2.5 x 1...Continue Reading

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