Developmental sub-chronic exposure to chlorpyrifos reduces anxiety-related behavior in zebrafish larvae.

Neurotoxicology and Teratology
Holly RichendrferRobbert Créton

Abstract

Neurobehavioral disorders such as anxiety, autism, and attention deficit hyperactivity disorders are typically influenced by genetic and environmental factors. Although several genetic risk factors have been identified in recent years, little is known about the environmental factors that either cause neurobehavioral disorders or contribute to their progression in genetically predisposed individuals. One environmental factor that has raised concerns is chlorpyrifos, an organophosphate pesticide that is widely used in agriculture and is found ubiquitously in the environment. In the present study, we examined the effects of sub-chronic chlorpyrifos exposure on anxiety-related behavior during development using zebrafish larvae. We found that sub-chronic exposure to 0.01 or 0.1 μM chlorpyrifos during development induces specific behavioral defects in 7-day-old zebrafish larvae. The larvae displayed decreases in swim speed and thigmotaxis, yet no changes in avoidance behavior were seen. Exposure to 0.001 μM chlorpyrifos did not affect swimming, thigmotaxis, or avoidance behavior and exposure to 1 μM chlorpyrifos induced behavioral defects, but also induced defects in larval morphology. Since thigmotaxis, a preference for the edge, is...Continue Reading

References

May 7, 1999·Environmental Health Perspectives·T A Slotkin
Sep 29, 2004·Neurotoxicology and Teratology·Edward D LevinElwood Linney
Jun 3, 2005·The American Journal of Psychiatry·Suniti Chakrabarti, Eric Fombonne
Aug 17, 2005·Toxicology and Applied Pharmacology·Angela S HowardPamela J Lein
Jun 9, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Laura RicceriGemma Calamandrei
Aug 26, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Christopher TonCatherine Willett
Nov 1, 2008·Archives of Women's Mental Health·Marysia J LazinskiMeir Steiner
May 30, 2009·Ecotoxicology and Environmental Safety·Cornelia KienleAlmut Gerhardt
Jan 19, 2010·Nature Chemical Biology·David KokelRandall T Peterson
Mar 10, 2010·Neurotoxicology and Teratology·Ingrid W T SelderslaghsHilda E Witters
Jun 1, 2010·Behavioural Brain Research·Caio MaximinoAmauri Gouveia
Jun 15, 2010·Behavioural Brain Research·Danielle L ChampagneMichael K Richardson
Jun 15, 2010·Toxicology and Industrial Health·Turgay Sişman
Aug 3, 2010·Behavioural Brain Research·Omar AhmedRobert Gerlai
Dec 15, 2010·Behavioural Processes·Ruth M Colwill, Robbert Creton
Jan 5, 2011·Neuroscience and Biobehavioral Reviews·Diane Dufour-RainfrayChristian R Andres
Feb 25, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Dongren YangPamela J Lein
May 10, 2011·Behavioural Brain Research·Sean D PelkowskiRobbert Creton
May 17, 2011·Reviews in the Neurosciences·Ruth M Colwill, Robbert Creton
Jul 13, 2011·Neurotoxicology and Teratology·Damiyon SledgeEdward D Levin
Oct 4, 2011·Neurotoxicology and Teratology·Jiangfei ChenQiaoxiang Dong
Dec 14, 2011·Behavioural Brain Research·H RichendrferR Creton
Feb 14, 2012·Developmental Neurobiology·Suresh Jesuthasan

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Citations

Jul 16, 2013·Journal of Visualized Experiments : JoVE·Holly Richendrfer, Robbert Créton
Aug 26, 2014·Zebrafish·Danielle CliftRobbert Creton
Dec 7, 2013·Environmental Toxicology and Chemistry·Yu-Jie DaiDe-Sheng Pei
Oct 12, 2013·Environmental Toxicology and Chemistry·Maya A ZeinDavid K Pitts
Sep 14, 2012·Neurotoxicology and Teratology·Celine de EschDidima de Groot
Nov 26, 2015·Neurotoxicology and Teratology·Xiuyun LiuQiang Li
Mar 29, 2016·Neurotoxicology and Teratology·Liwei SunZhengwei Fu
Jul 3, 2015·Archives of Environmental Contamination and Toxicology·Nguyen Thanh TamNguyen Van Cong
Jun 28, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Danielle HagstromEva-Maria S Collins
Dec 10, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adam Michael StewartAllan V Kalueff
Jan 17, 2015·Behavioural Brain Research·Danielle E CliftRobbert Creton
May 25, 2016·Behavioural Brain Research·Daniel J DavisAaron C Ericsson
Jun 5, 2016·The Science of the Total Environment·Molly E Shuman-Goodier, Catherine R Propper
Dec 3, 2016·Environment International·Yael Abreu-Villaça, Edward D Levin
Jan 10, 2017·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K DaleS Ellingsen
Sep 7, 2018·Environmental Toxicology and Chemistry·Sara J McClellandSarah K Woodley
Feb 13, 2019·Drug and Chemical Toxicology·Simranjeet KaurD K Dhawan
May 26, 2017·Behavioural Pharmacology·Yongxia JiQiang Li
Aug 26, 2020·Psychopharmacology·Veronica B MaphangaAlvaro M Viljoen
May 2, 2018·Environmental Science and Pollution Research International·Nguyen Thanh TamNguyen Van Cong
Oct 20, 2018·Pediatric Research·James R RobertsJ Routt Reigart
Nov 13, 2018·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·P A OlsvikM Sanden
Jul 31, 2021·Environmental Toxicology and Chemistry·Shannon Weeks SantosJérôme Cachot

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