Oct 24, 2018

Developmental synaptic changes at the transient olivocochlear-inner hair cell synapse

BioRxiv : the Preprint Server for Biology
Graciela KearneyEleonora Katz

Abstract

In the mature mammalian cochlea, inner hair cells (IHCs) are mainly innervated by afferent fibers that convey sound information to the central nervous system. During postnatal development, however, medial olivocochlear (MOC) efferent fibers transiently innervate the IHCs. The MOC-IHC synapse, functional from postnatal day (P)0 to hearing onset (P12), undergoes dramatic changes in the sensitivity to acetylcholine (ACh) and in the expression of key postsynaptic proteins. To evaluate whether there are associated changes in the properties of ACh release during this period, we used a cochlear preparation from mice at P4, P6-7 and P9-11 and monitored transmitter release from MOC terminals in voltage-clamped IHCs in the whole-cell configuration. The quantum content increased 5.6x from P4 to P9-11 due to increases in the size and replenishment rate of the readily releasable pool (RRP) of synaptic vesicles, without changes in their probability of release (Pvesicle) or quantum size. This strengthening in transmission was accompanied by changes in the short-term plasticity (STP) properties, which switched from facilitation at P4 to depression at P9-11. We have previously shown that at P9-11, ACh release is supported by P/Q and N-type volt...Continue Reading

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Mentioned in this Paper

Voltage gated calcium channel
Presynaptic Terminals
Size
Cochlear Implant Procedure
Activation of Short-term Neuronal Synaptic Plasticity
Synaptic Vesicles
T-Type Calcium Channels
Calcium ion
Entire Central Nervous System
8-methoxycaffeine

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