Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size.

Developmental Biology
Lauren J WegmanWayne A Johnson

Abstract

Controlled organismal growth to an appropriate adult size requires a regulated balance between nutrient resources, feeding behavior and growth rate. Defects can result in decreased survival and/or reproductive capability. Since Drosophila adults do not grow larger after eclosion, timing of feeding cessation during the third and final larval instar is critical to final size. We demonstrate that larval food exit is preceded by a period of increased larval surfacing behavior termed the Intermediate Surfacing Transition (IST) that correlates with the end of larval feeding. This behavioral transition occurred during the larval Terminal Growth Period (TGP), a period of constant feeding and exponential growth of the animal. IST behavior was dependent upon function of a subset of peripheral sensory neurons expressing the Degenerin/Epithelial sodium channel (DEG/ENaC) subunit, Pickpocket1(PPK1). PPK1 neuron inactivation or loss of PPK1 function caused an absence of IST behavior. Transgenic PPK1 neuron hyperactivation caused premature IST behavior with no significant change in timing of larval food exit resulting in decreased final adult size. These results suggest a peripheral sensory mechanism functioning to alter the relationship betw...Continue Reading

References

Sep 12, 2000·Current Opinion in Genetics & Development·H Stocker, E Hafen
Nov 14, 2001·The Journal of Biological Chemistry·Michael J WelshJinghui Xie
Jan 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Laura A Johnston, Peter Gallant
Jun 28, 2002·Physiological Reviews·Stephan Kellenberger, Laurent Schild
Jan 14, 2003·Annual Review of Physiology·Miriam B Goodman, Erich M Schwarz
Feb 4, 2003·Nature Reviews. Molecular Cell Biology·Estela Jacinto, Michael N Hall
Mar 8, 2003·Evolution & Development·Goggy DavidowitzH Frederik Nijhout
Apr 23, 2003·Cell·W Daniel TraceySeymour Benzer
Aug 28, 2003·Developmental Biology·H F Nijhout
Sep 2, 2003·Trends in Neurosciences·Oleg Krishtal
Sep 6, 2003·Current Biology : CB·Joshua A AinsleyWayne A Johnson
Oct 15, 2003·Neuron·Yuh-Nung Jan, Lily Yeh Jan
Feb 26, 2004·Nature Genetics·Annette L ParksHelen L Francis-Lang
Feb 26, 2004·Nature Genetics·Stephen T ThibaultJonathan Margolis
Mar 17, 2004·Current Opinion in Neurobiology·Wesley B Grueber, Yuh Nung Jan
Apr 23, 2004·Trends in Cell Biology·Duojia PanXinsheng Gao
Sep 25, 2004·Journal of Neurobiology·Michael N NitabachTodd C Holmes
Oct 2, 2004·Nature Medicine·Mary-Elizabeth Patti, Barbara B Kahn
Jan 22, 2005·Science·Michael W Schwartz, Daniel Porte
Mar 23, 2005·Current Opinion in Cell Biology·Dietmar E Martin, Michael N Hall
Mar 26, 2005·Science·Michael K Badman, Jeffrey S Flier
Jun 1, 2005·Journal of Neuroscience Methods·Virginia A Min, Barry G Condron
Sep 24, 2005·Science·Julien ColombaniPierre Léopold
Oct 26, 2005·Current Biology : CB·Alexander W Shingleton
Jan 7, 2006·Nature Medicine·Simon Smyth, Andrew Heron
Jan 13, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Haojiang LuanBenjamin H White
Feb 8, 2006·Annual Review of Physiology·Tobias WangDavid J Randall
Feb 14, 2006·Cell·Stephan WullschlegerMichael N Hall
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Cullen M TaniguchiC Ronald Kahn
Mar 22, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Christen Kerry Mirth, Lynn M Riddiford
Apr 14, 2007·The Journal of Biological Chemistry·Eric Lingueglia
May 8, 2007·Cell·Benjamin J MatthewsWesley B Grueber
May 18, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alexander W ShingletonDouglas J Emlen
Jun 21, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·A Oswal, G S H Yeo
Dec 7, 2007·Current Biology : CB·Richard Y HwangW Daniel Tracey
Oct 16, 2008·Developmental Cell·H Frederik Nijhout
Oct 16, 2008·Developmental Cell·Sophie LayallePierre Léopold
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S O'Rahilly, I S Farooqi

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Citations

Jan 18, 2014·BMC Neuroscience·Myung-Jun Kim, Wayne A Johnson
Jul 22, 2014·Current Biology : CB·Dana Shani GaliliHiromu Tanimoto
Nov 22, 2016·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Kaori WatanabeTadashi Uemura
Jun 10, 2018·Scientific Reports·Deborah L LloydAndrew O M Wilkie
Oct 3, 2018·Proceedings of the National Academy of Sciences of the United States of America·Lin Ling, Alexander S Raikhel
Oct 22, 2016·Archives of Insect Biochemistry and Physiology·Joseph Woodring, Sandy Weidlich
Sep 4, 2021·Bioelectricity·Pranjal SrivastavaMichael Levin

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