Developmental toxic potential of di-n-propyl phthalate administered orally to rats

Journal of Applied Toxicology : JAT
Anne-Marie SaillenfaitMarie-Christine Chagnon

Abstract

The objective of this study was to evaluate the developmental toxic potential of di-n-propyl phthalate (DnPP) in rats. Pregnant Sprague-Dawley rats were given DnPP at doses of 0 (olive oil), 0.5, 1 and 1.5 g kg⁻¹ per day, by gavage, on gestation days 6-20. Benchmark doses were calculated for the effects of DnPP on fetal weight and anogenital distance of the male fetuses. Maternal body weight gain was significantly reduced at 1.5 g kg⁻¹ per day, over gestation days 6-9. DnPP-treated dams also showed a statistically significant increase in liver weight and a mild but statistically significant peroxisomal enzyme induction at 1 or 1.5 g kg⁻¹ per day. Male and female fetal body weights were significantly reduced at 1.5 g kg⁻¹ per day. There was a statistically significant decrease in the anogenital distance of the male fetuses at 1 and 1.5 g kg⁻¹ per day, and three males (of 75) showed malpositioned testis at the high dose. The mean percentage of fetuses per litter with cervical and thoracic rudimentary ribs was significantly increased at 1 and 1.5 g kg⁻¹ per day. Delayed ossification was seen at 1 g kg⁻¹ per day (phalanges) and 1.5 g kg⁻¹ per day (hyoid, sternebrae, and phalanges). No treatment-related effects on prenatal viability...Continue Reading

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Citations

Sep 13, 2011·Reproductive Toxicology·Anne-Marie SaillenfaitJean-Philippe Sabaté
Feb 15, 2013·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
Jun 7, 2014·Critical Reviews in Toxicology·Vanessa R KayWarren G Foster
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Jul 30, 2017·Birth Defects Research·Pushkor MukerjiJoseph M Lewis
Dec 12, 2012·Current Opinion in Endocrinology, Diabetes, and Obesity·Sara A DiVall
Nov 30, 2019·Frontiers in Pharmacology·Yiyan WangRen-Shan Ge

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