Developmental toxicity evaluation of three hexabromocyclododecane diastereoisomers on zebrafish embryos

Aquatic Toxicology
Miaomiao DuXian Zhang

Abstract

Structural dissimilarities of hexabromocyclododecane diastereoisomers could raise substantial differences in physicochemical, biological and toxicological properties. In order to fully assess the environmental safety and health risk of hexabromocyclododecanes (HBCDs), zebrafish embryos were used to evaluate the developmental toxicity of individual HBCD diastereoisomers (α-HBCD, β-HBCD and γ-HBCD). Four-hour post-fertilization (hpf) zebrafish embryos were exposed to different concentrations of HBCD diastereoisomers (0, 0.01, 0.1 and 1.0 mg/l) until 120 hpf. The results showed that exposure to HBCDs can affect the development of zebrafish embryos/larvae in a dose-dependent and diastereoselective manner. The diastereoisomers α-, β- and γ-HBCD at 0.01 mg/l had little effect on the development of zebrafish embryos except that exposure to 0.01 mg/l γ-HBCD significantly delayed hatching (P<0.05). At 0.1mg/l, α-HBCD resulted in depressed heart rate of larvae (96 hpf) and delayed hatching, whereas β- and γ-HBCD both caused significant hatching delay and growth inhibition (P<0.05). In addition, a remarkable and significant increase in mortality and malformation rate was noted at 0.1 mg/l γ-HBCD exposure groups (P<0.05). At 1.0 mg/l, α-, ...Continue Reading

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