PMID: 9434863Jan 22, 1998Paper

Developmental toxicity induced during early stages of mammalian embryogenesis

Mutation Research
J C Rutledge

Abstract

Both a conceptual and a practical borderland between teratology and mutagenesis is early embryogenesis, the period between fertilization and gastrulation. Radiation and a variety of chemicals adversely affect the early conceptus leading to in utero mortality and malformations. The post-fertilization period of susceptibility differs from exposures of gametes, the later producing excessive pre- and peri-implantational death and low rates of fetal anomalies predominated by growth retardation. In contrast mutagen exposure of the zygote induces peri-implantational death, pan-gestational death and fetal anomalies predominated by hydrops, abdominal wall defects, and eye aberrations. The mechanism for this pathology remains unclear. These same agents produce a broader range of phenotypic anomalies during the remainder of pre-gastrulation development with anomalies overlapping those induced during organogenesis. Retinoic acid and 5-azacytidine administered prior to gastrulation produce novel malformation syndromes indicative of gene expression modification. The rates and types of defects from mutagen treatment of both gametes and the early conceptus contrast with those resulting from embryonic treatment during organogenesis, and the mec...Continue Reading

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Citations

Mar 15, 2000·Teratology·J Rutledge
May 4, 2001·Annales de génétique·C StollP Mastroiacovo
Jan 22, 1998·Mutation Research·L R Ferguson, J H Ford
Jan 22, 1998·Mutation Research·J B BishopR A Sloane
Nov 8, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J RohwedelA M Wobus
Jan 18, 2003·Risk Analysis : an Official Publication of the Society for Risk Analysis·Andrew S Allen, Huiman X Barnhart
Sep 23, 2010·Genome Biology·Stefan ThomsenClaudio R Alonso
May 26, 1999·Environmental Health Perspectives·J DejmekR J Srám
Jan 8, 2000·Environmental Health Perspectives·R Srám
Feb 8, 2007·Emerging Infectious Diseases·Joanne ConoSonja A Rasmussen
May 9, 2009·Neurological Research·Mohammad Taghi GhorbanianYaghoub Fathollahi
Mar 31, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·C HidalgoE Gómez
Dec 29, 2007·Critical Reviews in Toxicology·R J Dinis-OliveiraF Carvalho
Jan 7, 2015·Pharmacology & Therapeutics·Sonali ReisingerDaniela D Pollak
Dec 4, 2008·Advances in Pediatrics·Jaime L Frías, Enid Gilbert-Barness
Jun 14, 2008·Reproductive Toxicology·Karen CruttendenValquiria A C Dorce
Jul 19, 2012·Birth Defects Research. Part A, Clinical and Molecular Teratology·Margaret P Adam
Jan 17, 2008·The Journal of Toxicological Sciences·Ryohei YokoiTamao Ono
Dec 17, 2008·American Journal of Obstetrics and Gynecology·Anne L DunlopMelissa A McDiarmid
Mar 12, 2004·Developmental Biology·Stephanie Brewer, Trevor Williams
Apr 4, 2017·Fetal and Pediatric Pathology·Zeynep Ozturk, Emine Akgul
Nov 20, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Stephanie Brewer, Trevor Williams
Oct 9, 2003·Annals of the ICRP·Roger Cox, Christian Streffer
Oct 4, 2012·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·P Jacquet

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