Developmental Toxicity of Ethanolic Extracts of Leaves of Achyranthes aspera, Amaranthaceae in Rat Embryos and Fetuses.

Journal of Experimental Pharmacology
Daniel TeshomeZebader Walle Belete

Abstract

Achyranthes aspera is one of the medicinal plants widely used for fertility control in the local health system of Ethiopia. Assessment of developmental toxicity of ethanolic extracts of leaves of Achyranthes aspera in rat embryos and fetuses. Fresh leaves were extracted by mixing the grinded powder with 70% ethanol. Then, the extract was given orally to gravid Wistar rats at doses of 250 mg/kg, 500 mg/kg and 1000 mg/kg from day 6-12 of gestation. On gestational days 12 and 20, embryos and fetuses were examined for developmental and gross malformations. On day 12 embryos, the number of implantation sites and somites in 1000 mg/kg treated rats were significantly reduced. The number of implantation sites in pair-fed control and 1000 mg/kg groups was 11.2±0.86 and 8.34±0.65, respectively. Retarded development of hindlimb, forelimb, optic and olfactory systems was detected at a high dose. In addition, the number of branchial bar was significantly reduced in 1000 mg/kg dose. In near-term fetuses, significant reduction of litter weight and crown-rump length was seen at 1000 mg/kg dose. Crown-rump length in pair-fed control and 1000 mg/kg treated groups was 2.82±0.17 cm and 2.31±0.11 cm, respectively. Fetal resorptions and deaths in 10...Continue Reading

References

May 27, 2006·Journal of Ethnopharmacology·Neeru Vasudeva, S K Sharma
Jan 22, 2010·Journal of Ethnobiology and Ethnomedicine·Taiwo E Mafimisebi, Adegboyega E Oguntade
Dec 3, 2011·Journal of Ethnobiology and Ethnomedicine·Wubet BirhanTilahun Teklehaymanot
Sep 1, 2010·Journal of Dietary Supplements·Shao-Kang Hung, Edzard Ernst
Jul 10, 2012·Journal of Ethnopharmacology·Abraham FikruGetinet Abie Mekonnen
Dec 18, 2013·Birth Defects Research. Part C, Embryo Today : Reviews·Benedict T GreenKip E Panter
Dec 18, 2019·Open Access Macedonian Journal of Medical Sciences·Velmurugan ChinnasamyShafiulla Muhammad
Feb 26, 2021·BioMed Research International·Daniel TeshomeGete Berihun

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