Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats

Teratology
K A TreinenW F Blazak

Abstract

Mangafodipir trisodium (MnDPDP) is a manganese chelate being developed as a contrast agent for magnetic resonance imaging of the hepatobiliary system. The intended clinical dose is 5 mumol/kg. The potential for MnDPDP to induce embryotoxicity and/or teratogenicity in Sprague-Dawley rats was investigated. Twenty five inseminated rats/group were intravenously administered 0, 2, 5, or 20 mumol/kg MnDPDP from days 6-17 of gestation. Maternal toxicity was not observed at any dose of MnDPDP. There were no treatment-related effects on the numbers of fetuses, fetal viability, numbers of resorptions, implantations and corpora lutea, or the percent of pre- and post-implantation losses. However, at 20 mumol/kg, fetal body weights were significantly decreased (3.3 g vs. 3.9 g for control) and increased skeletal malformations were observed (141/270 vs. 0/285 in control). The malformations were of a specific type, which included angulated or irregularly shaped clavicle, femur, fibula, humerus, ilium, radius, scapula, tibia, and/or ulna. To better define the developmental stage that is most susceptible to the effects of MnDPDP, a segmented developmental study was conducted. Twelve inseminated rats were administered 0, 20, 40, or 80 mumol/kg M...Continue Reading

References

Feb 1, 1978·Toxicology·H S ButtarK S Khera
Jan 1, 1975·Naunyn-Schmiedeberg's Archives of Pharmacology·H J MerkerT Günther
Jan 1, 1971·Clinical Orthopaedics and Related Research·W R KingW R Michael
Apr 1, 1981·Physiological Reviews·L S Hurley
Jul 1, 1993·Toxicology Letters·D J SánchezC L Keen
Oct 1, 1963·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·Y KOSHIDAT HARA

❮ Previous
Next ❯

Citations

Nov 25, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R KroesUNKNOWN European branch of the International Life Sciences Institute
Mar 1, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D Doyle, C M Kapron
Mar 30, 2002·Critical Reviews in Oncology/hematology·G B GerberPh Hantson
Mar 8, 2002·Investigative Radiology·Michael F Tweedle
Jul 23, 2013·PloS One·Marsha A GastonAlison A Weiss
Apr 2, 2013·European Journal of Public Health·Huai GuanKazuhito Yokoyama
May 13, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Annabelle BertinDelphine Felder-Flesch
Feb 5, 2008·Reproductive Toxicology·Mohsen VigehShunichi Araki
Dec 24, 2004·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert L ClarkStephen Andrew Ward
Dec 24, 2004·NMR in Biomedicine·Janelle Crossgrove, Wei Zheng
Jun 20, 2018·Birth Defects Research·John M DeSesso, Anthony R Scialli
Aug 16, 2018·Scientific Reports·Andrei VenterHai-Ling Margaret Cheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
K A MuettertiesD L White
Toxicological Sciences : an Official Journal of the Society of Toxicology
Peter L Goering
Ecotoxicology and Environmental Safety
R Maci, E Arias
© 2021 Meta ULC. All rights reserved