PMID: 8954749Dec 1, 1996Paper

Developmental toxicity of PCB 126 (3,3',4,4',5-pentachlorobiphenyl) in nestling American kestrels (Falco sparverius)

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
D J HoffmanG W Pendleton

Abstract

Planar PCB congeners are embryotoxic and teratogenic to birds including American kestrels. The developmental toxicity of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) was studied in the posthatching kestrel as a model for the eagle. Nestlings were dosed orally for 10 days with 5 microl/g body weight of corn oil (controls) or the planar PCB 126 at concentrations of 50, 250, or 1000 ng/g body weight. Dosing with 50 ng/g of PCB 126 resulted in a hepatic concentration of 156 ng/g wet weight, liver enlargement and mild coagulative necrosis, over 10-fold increases in hepatic microsomal ethoxyresorufin-O-dealkylase and benzyloxyresorufin-O-dealkylase, and approximately a 5-fold increase in methoxyresorufin-O-dealkylase. At this dose, mild to moderate lymphoid depletion of the spleen was apparent, as were decreased follicle size and content of the thyroid. At 250 ng/g, concentration of PCB 126 in the liver was 380 ng/g with increasing multifocal coagulative necrosis, decreased bone growth, decreased spleen weight with lymphocyte depletion of the spleen and bursa, and degenerative lesions of the thyroid. At 1000 ng/g, the liver concentration was 1098 ng/g, accompanied by decreased bursa weight, decreased hepatic thiol concentration, and inc...Continue Reading

Citations

Feb 27, 2004·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·A L KatynskiT W Moon
Jan 16, 2002·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·J J SchlezingerJ J Stegeman
Oct 3, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·K HilscherovaJ P Giesy
Nov 30, 1998·Environmental Health Perspectives·M Van den BergT Zacharewski
Apr 15, 2008·Ecotoxicology and Environmental Safety·Virginie GillardinPatrick Kestemont
Apr 29, 2008·Environmental Toxicology and Pharmacology·Sandor SipkaMichal Toborek
Jul 3, 2003·Environmental Toxicology and Chemistry·Sheryl A TittlemierRoss J Norstrom
Sep 4, 2015·The Science of the Total Environment·Manuel E Ortiz-SantaliestraRafael Mateo
Apr 5, 2016·Chemosphere·Clare Isabel Ming-Ch'eng AdamsBirthe V Kjellerup
Sep 20, 2005·Ecotoxicology and Environmental Safety·Sheri A FisherJudit E Smits
Jul 21, 2016·Chemical Research in Toxicology·Esra MutluJames A Swenberg
Oct 20, 2012·Toxicology and Industrial Health·Roshni PandaP K Suresh
Mar 17, 2007·Journal of Toxicology and Environmental Health. Part a·Yue-wern HuangWilliam H Karasov
Sep 19, 2008·Journal of Toxicology and Environmental Health. Part a·Glen A FoxP Monica Lind
Oct 20, 1998·Thyroid : Official Journal of the American Thyroid Association·F Brucker-Davis
Jun 9, 2010·Journal of Toxicology and Environmental Health. Part a·Mark WaylandKatherine R Stebbins
Jul 21, 2006·Journal of Toxicology and Environmental Health. Part a·Sheri A FisherJudit E Smits
May 24, 2005·Reproduction, Fertility, and Development·Yixiang ZhangZandong Li
Aug 10, 2007·Journal of Toxicology and Environmental Health. Part a·Glen A FoxG Douglas Campbell
Aug 10, 2007·Journal of Toxicology and Environmental Health. Part a·Glen A FoxKeith A Grasman

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