PMID: 9441714Jan 27, 1998Paper

Developmental toxicity study in rats and rabbits administered an emulsion containing medium chain triglycerides as an alternative caloric source

Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology
S HenwoodS Trimbo

Abstract

Triglyceride-containing lipid emulsions have been designed as caloric sources that can be administered intravenously to patients that cannot meet their nutritional needs by conventional parenteral therapies. In their study, we evaluate the developmental toxicity of a 20% lipid emulsion that contains a 3:1 ratio of medium chain triglyceride (MCT) to one long chain containing lipid emulsion (LCT). This emulsion was administered by intravenous infusion to rats and rabbits at dosages of 1 and 4.28 g lipid/kg body weight (g lipid/kg) at dose volumes of 5 and 21.4 mL/kg, respectively, once daily during organogenesis to assess the potential developmental toxicity of the test article. The control group received 0.9% saline at a dose volume of 21.4 mL/kg. Animals were observed for clinical signs of toxicity and adverse effects on body weights and feed consumption. On Day 20 (rats) or Day 29 (rabbits), females were necropsied and examined for maternal and embryo/fetal toxicity. Fetuses were removed, weighed, and examined for external, soft tissue, and skeletal abnormalities. Dosages of 4.28 g lipid/kg resulted in lower feed consumption for rats and rabbits, an expected finding based on the high-caloric nature of the test article. Potenti...Continue Reading

Citations

Feb 24, 2000·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K A TraulD Nakhasi
Jan 13, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ray A MatulkaGeorge A Burdock
Oct 1, 2013·Expert Opinion on Drug Metabolism & Toxicology·Evan A Thackaberry

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