Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice

Cerebral Cortex
Caitlin E MoyerRobert A Sweet

Abstract

Cortical excitatory and inhibitory synapses are disrupted in schizophrenia, the symptoms of which often emerge during adolescence, when cortical excitatory synapses undergo pruning. In auditory cortex, a brain region implicated in schizophrenia, little is known about the development of excitatory and inhibitory synapses between early adolescence and young adulthood, and how these changes impact auditory cortex function. We used immunohistochemistry and quantitative fluorescence microscopy to quantify dendritic spines and GAD65-expressing inhibitory boutons in auditory cortex of early adolescent, late adolescent, and young adult mice. Numbers of spines decreased between early adolescence and young adulthood, during which time responses increased in an auditory cortex-dependent sensory task, silent gap-prepulse inhibition of the acoustic startle reflex (gap-PPI). Within-bouton GAD65 protein and GAD65-expressing bouton numbers decreased between late adolescence and young adulthood, a delay in onset relative to spine and gap-PPI changes. In mice lacking the spine protein kalirin, there were no significant changes in spine number, within-bouton GAD65 protein, or gap-PPI between adolescence and young adulthood. These results illustra...Continue Reading

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Citations

Jan 1, 2015·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V G Kaleda
Mar 30, 2017·Frontiers of Medicine·Qin YangFangyi Chen
Jun 4, 2020·Journal of the Association for Research in Otolaryngology : JARO·Jennifer D GayJulia Jones Huyck
Dec 2, 2021·Proceedings of the National Academy of Sciences of the United States of America·Melanie J GrubishaRobert A Sweet

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