Developmental trajectories of brain maturation and behavior: Relevance to major mental illnesses.

Journal of Pharmacological Sciences
Sedona LockhartMinae Niwa

Abstract

Adverse events in childhood and adolescence, such as social neglect or drug abuse, are known to lead to behavioral changes in young adulthood. This is particularly true for the subset of people who are intrinsically more vulnerable to stressful conditions. Yet the underlying mechanisms for such developmental trajectory from early life insult to aberrant adult behavior remains elusive. Adolescence is a period of dynamic physiological, psychological, and behavioral changes, encompassing a distinct neurodevelopmental stage called the 'critical period'. During adolescence, the brain is uniquely susceptible to stress. Stress mediators may lead to disturbances to biological processes that can cause permanent alterations in the adult stage, even as severe as the onset of mental illness when paired with genetic risk and environmental factors. Understanding the molecular factors governing the critical period and how stress can disturb the maturation processes will allow for better treatment and prevention of late adolescent/young adult onset psychiatric disorders.

References

Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
Jul 13, 2000·Archives of General Psychiatry·T H McGlashan, R E Hoffman
Jan 10, 2001·Annual Review of Psychology·L Steinberg, A S Morris
Nov 26, 2002·BMJ : British Medical Journal·Louise ArseneaultTerrie E Moffitt
Aug 19, 1964·Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie·D H HUBEL, T N WIESEL
Jun 23, 2004·Nature Reviews. Neuroscience·Lisa M Boulanger, Carla J Shatz
Jun 26, 2004·Annual Review of Neuroscience·Takao K Hensch
Jul 5, 2006·Cerebral Cortex·Kuei-Yuan Tseng, Patricio O'Donnell
Apr 25, 2007·Nature Reviews. Neuroscience·Nadia TsankovaEric J Nestler
Mar 11, 2008·Trends in Neurosciences·Susan L Andersen, Martin H Teicher
Nov 13, 2008·Nature Reviews. Neuroscience·Tomás PausJay N Giedd
Apr 30, 2009·Nature Reviews. Neuroscience·Sonia J LupienChristine Heim
Jan 21, 2010·Nature Reviews. Neuroscience·Peter J Uhlhaas, Wolf Singer
Sep 24, 2015·Molecular Psychiatry·M A Landek-SalgadoA Sawa
Sep 22, 2017·Nature Reviews. Neuroscience·Urte Neniskyte, Cornelius T Gross
Dec 12, 2017·Cell·Hsin-Kai LiaoJuan Carlos Izpisua Belmonte
Feb 23, 2018·Nature·Ronald E DahlAhna Ballonoff Suleiman

❮ Previous
Next ❯

Citations

Jul 28, 2019·Journal of Neural Transmission·Nicola LopizzoAnnamaria Cattaneo
Jun 13, 2021·Journal of Substance Abuse Treatment·Lisa D Hawke, Joanna Henderson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.