Developmental Trajectories of Cortical Thickness in Relation to Schizotypy During Adolescence.

Schizophrenia Bulletin
Mélodie DeromeMartin Debbané

Abstract

Investigating potential gray matter differences in adolescents presenting higher levels of schizotypy personality traits could bring further insights into the development of schizophrenia spectrum disorders. Research has yet to examine the morphological correlates of schizotypy features during adolescence prospectively, and no information is available on the developmental trajectories from adolescence to adulthood. We employed mixed model regression analysis to investigate developmental trajectories of cortical thickness (CT) in relation to schizotypy dimensions in a cohort of 109 adolescents from the general population for whom MRI-scans were acquired over a 5-year period, culminating in a total of 271 scans. Structural data were processed with FreeSurfer software, statistical analyses were conducted using mixed regression models following a ROI-based approach, and schizotypy was assessed with the Schizotypal Personality Questionnaire (SPQ). Accelerated thinning was observed in the posterior cingulate cortex in relation to high levels of positive schizotypy, whereas high levels of disorganized schizotypy were associated with a similar trajectory pattern in the anterior cingulate cortex. The developmental course of CT in the pr...Continue Reading

References

May 1, 1995·The British Journal of Psychiatry : the Journal of Mental Science·S E Chua, P J McKenna
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·P M ThompsonJ L Rapoport
Dec 26, 2001·Archives of General Psychiatry·H E Hulshoff PolR S Kahn
Dec 26, 2001·Harvard Review of Psychiatry·Chandlee C DickeyMartha E Shenton
Sep 10, 2003·Archives of General Psychiatry·Gina R KuperbergBruce Fischl
Jul 5, 2005·Biological Psychiatry·Katherine L NarrRobert M Bilder
Jan 13, 2006·Schizophrenia Bulletin·Emma BarkusShôn Lewis
Feb 15, 2008·Schizophrenia Research·Erin A HazlettLarry J Siever
Sep 1, 2009·Biological Psychiatry·Joost JanssenCelso Arango
Oct 17, 2009·Psychiatry Research·Thomas William James MoorheadEve Johnstone
Jul 9, 2010·Biological Psychiatry·Lars M RimolIngrid Agartz
Jul 20, 2010·NeuroImage·Martin ReuterBruce Fischl
Oct 12, 2010·Schizophrenia Bulletin·Tim B ZiermansSarah Durston
Mar 8, 2011·NeuroImage·Martin Reuter, Bruce Fischl
May 4, 2011·Archives of General Psychiatry·Andrea MechelliPhilip McGuire
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
Mar 7, 2014·Frontiers in Psychiatry·Ulrich EttingerNikolaos Koutsouleris
Jun 4, 2014·Psychiatry Research·Eduardo Fonseca-PedreroJosé Muñiz
Jun 22, 2014·Brain : a Journal of Neurology·Remko van LutterveldIris E Sommer
Jul 19, 2014·Biological Psychiatry·Tyrone D CannonUNKNOWN North American Prodrome Longitudinal Study Consortium
Dec 31, 2014·Schizophrenia Bulletin·Martin DebbanéFrauke Schultze-Lutter
Sep 4, 2015·Schizophrenia Research·Betty M TijmsStephen M Lawrie
Jan 24, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Rebecca E WatskyAnna E Ordóñez
May 22, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Kristina WiebelsHaeme R P Park
Aug 31, 2016·Early Intervention in Psychiatry·Laila AsmalRobin Emsley
Sep 2, 2016·Journal of Abnormal Psychology·Rahel FlückigerFrauke Schultze-Lutter
Oct 8, 2016·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Maude SchneiderStephan Eliez
Mar 1, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christian K TamnesKathryn L Mills
Dec 5, 2017·Psychological Medicine·Gemma ModinosSteve C R Williams
Jun 1, 2019·NeuroImage. Clinical·Yoonho ChungUNKNOWN North American Prodrome Longitudinal Study (NAPLS) Consortium

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Citations

Jan 26, 2021·Frontiers in Psychiatry·Penny KaramaounaStella G Giakoumaki

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