Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use.

Alcoholism, Clinical and Experimental Research
Daniel E IronsMatt McGue

Abstract

In the aldehyde dehydrogenase 2 (ALDH2) gene, the ALDH2*2 allele, prevalent in East Asian populations, encodes an enzyme with severely reduced activity, thereby disrupting the normal metabolism of alcohol. Possession of the ALDH2*2 allele has been repeatedly shown to be associated with lower risk for alcohol dependence and reduced alcohol use. However, relatively few studies have considered whether the magnitude of the effect of ALDH2 polymorphism upon drinking is related to developmental stage or varies by environmental context. In a longitudinally assessed sample of 356 adopted adolescents and young adults of East Asian descent, we examined the progression over time of the relationship between ALDH2 genotype and multiple measures of drinking behavior. We also sought to determine whether the environmental influences of nonbiological parent and elder sibling alcohol use and misuse, as well as deviant peer behavior, moderated the effect of ALDH2 genotype upon alcohol use. Across all measures of alcohol use, the association between ALDH2*2 allele possession and reduced drinking went from negligible to moderate between mid-adolescence and early adulthood. A combined index of adoptive parent alcohol use and misuse consistently mode...Continue Reading

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Citations

Oct 16, 2012·Development and Psychopathology·Scott I VriezeMatt McGue
Dec 7, 2013·World Journal of Gastroenterology : WJG·Sonia RomanArturo Panduro
Feb 7, 2015·Addictive Behaviors·Suzanne H W MaresRutger C M E Engels
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Sep 27, 2014·Alcoholism, Clinical and Experimental Research·Emily OlfsonLaura J Bierut
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Danielle M DickSally I-Chun Kuo
May 5, 2017·The American Journal of Drug and Alcohol Abuse·Taryn O'SheaKaren G Chartier
Jul 25, 2017·Prevention Science : the Official Journal of the Society for Prevention Research·Danielle M Dick
Dec 23, 2020·Alcoholism, Clinical and Experimental Research·Won Kim CookLibo Li

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