Developmental white matter microstructure in autism phenotype and corresponding endophenotype during adolescence

Translational Psychiatry
D M LisieckaJ Suckling

Abstract

During adolescence, white matter microstructure undergoes an important stage of development. It is hypothesized that the alterations of brain connectivity that have a key role in autism spectrum conditions (ASCs) may interact with the development of white matter microstructure. This interaction may be present beyond the phenotype of autism in siblings of individuals with ASC, who are 10 to 20 times more likely to develop certain forms of ASC. We use diffusion tensor imaging to examine how white matter microstructure measurements correlate with age in typically developing individuals, and how this correlation differs in n=43 adolescents with ASC and their n=38 siblings. Correlations observed in n=40 typically developing individuals match developmental changes noted in previous longitudinal studies. In comparison, individuals with ASC display weaker negative correlation between age and mean diffusivity in a broad area centred in the right superior longitudinal fasciculus. These differences may be caused either by increased heterogeneity in ASC or by temporal alterations in the group's developmental pattern. Siblings of individuals with ASC also show diminished negative correlation between age and one component of mean diffusivity...Continue Reading

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Software Mentioned

Brain Extraction Tool FSL
FMRIB Software Library ( FSL )
FMRIB
DTIFit
FSL FMRIB Diffusion Toolbox
FSL
FSL General Linear Model
Diffusion Toolbox

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