Developmentally delayed cleavage-stage embryos maintain comparable implantation rates in frozen embryo transfers

Journal of Assisted Reproduction and Genetics
Heather BurksRichard Paulson

Abstract

In fresh IVF cycles, embryos reaching the eight-cell stage on day 3 of development are thought to have a higher chance of implantation than those reaching this stage on day 4. To determine whether this difference persists after cryopreservation, we compared pregnancy and implantation rates between frozen embryo transfer (FET) cycles using delayed cleavage-stage embryos (cryopreserved day 4) and normal cleavage-stage embryos (cryopreserved day 3). Participants underwent FET between 2008 and 2012 using embryos cryopreserved on either day 3 (n = 76) or day 4 (n = 48), depending on the length of time needed to achieve the eight-cell stage. All embryos, regardless of day of cryopreservation, were thawed and transferred on the 4th day of vaginal progesterone following endometrial preparation with oral estradiol. Chi-square and Mann-Whitney U tests were used to compare patient demographics and cycle outcomes. More women in the day 4 group had diminished ovarian reserve (44 vs 16 %, p = 0.003). Pregnancy outcomes in preceding fresh cycles were not different between the two groups. Pregnancy, implantation, and live birth rates following FET did not differ between the day 3 and day 4 groups. This is the first study to address outcomes us...Continue Reading

References

Jan 8, 2008·Fertility and Sterility·Eric D LevensFrederick W Larsen
Jun 24, 2010·Human Reproduction·J de MouzonUNKNOWN European IVF-monitoring (EIM) Consortium, for the European Society of Human Reproduction and Embryology (ESHRE)
Sep 8, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·T El-ToukhyP Braude
Jun 14, 2014·Reproductive Biomedicine Online·Laura van LoenderslootSjoerd Repping
Oct 14, 2014·Journal of Assisted Reproduction and Genetics·Ping ZhaoJie Qiao

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Citations

Apr 6, 2020·Journal of Assisted Reproduction and Genetics·Islam M Saadeldin

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