Developmentally inspired human 'organs on chips'

Development
Donald E Ingber

Abstract

Although initially developed to replace animal testing in drug development, human 'organ on a chip' (organ chip) microfluidic culture technology offers a new tool for studying tissue development and pathophysiology, which has brought us one step closer to carrying out human experimentation in vitro In this Spotlight article, I discuss the central role that developmental biology played in the early stages of organ-chip technology, and how these models have led to new insights into human physiology and disease mechanisms. Advantages and disadvantages of the organ-chip approach relative to organoids and other human cell cultures are also discussed.

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Citations

Jul 6, 2019·Médecine sciences : M/S·Charlotte FlatresMaxime M Mahé
Feb 26, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pierfrancesco PagellaThimios A Mitsiadis
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Apr 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chia-Yu ChangTsung-Jung Ho
Apr 24, 2020·Fluids and Barriers of the CNS·Michael J Workman, Clive N Svendsen
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