Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla

The Journal of Immunology : Official Journal of the American Association of Immunologists
Guillaume E DesantiGraham Anderson

Abstract

T cell tolerance in the thymus is a key step in shaping the developing T cell repertoire. Thymic medullary epithelial cells play multiple roles in this process, including negative selection of autoreactive thymocytes, influencing thymic dendritic cell positioning, and the generation of Foxp3(+) regulatory T cells. Previous studies show that medullary thymic epithelial cell (mTEC) development involves hemopoietic cross-talk, and numerous TNFR superfamily members have been implicated in this process. Whereas CD40 and RANK represent key examples, interplay between these receptors, and the individual cell types providing their ligands at both fetal and adult stages of thymus development, remain unclear. In this study, by analysis of the cellular sources of receptor activator for NF-κB ligand (RANKL) and CD40L during fetal and adult cross-talk in the mouse, we show that the innate immune cell system drives initial fetal mTEC development via expression of RANKL, but not CD40L. In contrast, cross-talk involving the adaptive immune system involves both RANKL and CD40L, with analysis of distinct subsets of intrathymic CD4(+) T cells revealing a differential contribution of CD40L by conventional, but not Foxp3(+) regulatory, T cells. We ...Continue Reading

References

Aug 1, 1992·The Journal of Experimental Medicine·C D SurhJ Sprent
Nov 1, 1994·The Journal of Experimental Medicine·B R RenshawC R Maliszewski
Jan 1, 1994·European Journal of Immunology·D BrändleH Pircher
Jan 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R J DunnA G Farr
Feb 26, 2000·The Journal of Investigative Dermatology·J GroussonJ Péguet-Navarro
Mar 3, 2004·Nature Immunology·Tamar E BoursalianPamela J Fink
Oct 20, 2004·The Journal of Experimental Medicine·Adrian ListonChristopher C Goodnow
Oct 20, 2004·The Journal of Experimental Medicine·Alena M Gallegos, Michael J Bevan
Feb 24, 2006·Nature Reviews. Immunology·Yousuke Takahama
Nov 23, 2006·The Journal of Experimental Medicine·Jason DeVossMark S Anderson
May 16, 2007·The Journal of Experimental Medicine·Simona W RossiGraham Anderson
May 18, 2007·Annual Review of Cell and Developmental Biology·Maria Ciofani, Juan Carlos Zúñiga-Pflücker
Jun 2, 2007·Science·Shigeo MurataKeiji Tanaka
Oct 3, 2007·The Journal of Experimental Medicine·Tom M McCaughtryKristin A Hogquist
Oct 3, 2007·The Journal of Experimental Medicine·Daniel GrayDiane Mathis
Nov 15, 2007·European Journal of Immunology·Jana GäblerBruno Kyewski
Jan 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Philip J Spence, E Allison Green
Oct 1, 2008·The Journal of Experimental Medicine·Katsuto HozumiSonoko Habu
Oct 1, 2008·The Journal of Experimental Medicine·Ute KochFreddy Radtke
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emma FioriniH Robson MacDonald
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Saba ShakibGraham Anderson
Mar 14, 2009·European Journal of Immunology·Julien GommeauxAlice Carrier
Jul 1, 2009·The Journal of Experimental Medicine·Christian Koble, Bruno Kyewski
Dec 17, 2009·Trends in Immunology·Magali IrlaWalter Reith
May 1, 2010·Nature Immunology·Maria HinterbergerLudger Klein
Sep 24, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea J WhiteGraham Anderson
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Vincent DuheronChristopher G Mueller
Mar 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuhiro MouriMitsuru Matsumoto
Apr 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katarzyna M SitnikWilliam W Agace
May 18, 2012·Trends in Immunology·Graham Anderson, Yousuke Takahama
May 23, 2012·Biochemical and Biophysical Research Communications·Ingrid LiivPärt Peterson

Citations

Jun 12, 2013·Journal of Biochemistry·Lynett Danks, Hiroshi Takayanagi
Mar 29, 2014·BioMed Research International·Lina SunYong Zhao
Jun 14, 2013·Clinical & Developmental Immunology·Nadia Lo IaconoCristina Sobacchi
Dec 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·S Rhiannon JenkinsonRichard J Hodes
Aug 11, 2015·Frontiers in Immunology·Noëlla LopesMagali Irla
Aug 8, 2015·Scientific Reports·Maude Dumont-LagacéClaude Perreault
Feb 23, 2017·Annual Review of Immunology·Jakub Abramson, Graham Anderson
Feb 28, 2017·Médecine sciences : M/S·Nadine DraginSonia Berrih-Aknin
Jan 21, 2016·PLoS Genetics·Dakshayani LomadaEllen R Richie
Jan 2, 2018·Annals of the New York Academy of Sciences·Sonia Berrih-AkninNadine Dragin
May 31, 2015·Annals of the Rheumatic Diseases·Lynett DanksHiroshi Takayanagi
Jun 4, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas A SpidaleRoland Tisch
Feb 11, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrea J WhiteGraham Anderson
Apr 19, 2016·Immunological Reviews·Beth LucasGraham Anderson
Apr 16, 2019·Frontiers in Immunology·Cristina SobacchiAnna Villa
Aug 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lina SunYong Zhao
Aug 9, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas I McCarthyGraham Anderson
Mar 29, 2018·Calcified Tissue International·Asuka Terashima, Hiroshi Takayanagi
Feb 22, 2020·Science·Jong-Eun ParkSarah A Teichmann
Jul 25, 2013·European Journal of Immunology·Isabel FerreroH Robson MacDonald
Mar 5, 2015·European Journal of Clinical Investigation·Myrthe A M van DelftSander W Tas
Feb 28, 2018·Frontiers in Immunology·Roberto Perniola
Nov 11, 2018·Journal of Clinical Medicine·Benjamin NavetFrédéric Lézot
Sep 10, 2020·Frontiers in Immunology·Sinéad Kinsella, Jarrod A Dudakov
Jan 14, 2021·Journal of Bone and Mineral Metabolism·Matthew C Walsh, Yongwon Choi
Mar 2, 2021·Frontiers in Immunology·Jérémy C SantamariaMagali Irla
Feb 22, 2021·Journal of Autoimmunity·Mohsen Khosravi-MaharlooeiMegan Sykes

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis