Developmentally regulated cell-cell adhesion in Dictyostelium purpureum is mediated by a glycoprotein synthesized in nonadhesive cells

Developmental Biology
W R Springer

Abstract

Upon starvation the cellular slime mold, Dictyostelium purpureum, develops a form of cell-cell adhesion aiding in the formation of large multicellular aggregates, which are capable of further differentiation. The molecule that mediates this adhesion is a glycoprotein of Mr approximately 40,000. The protein shares a common carbohydrate epitope with another well-characterized cell adhesion molecule from Dictyostelium discoideum, contact sites A, but the polypeptides to which it is attached differ for each species. Although mediating a developmental form of adhesiveness, the protein is synthesized in vegetative cells at a time when they do not adhere. Most of the vegetative protein is associated with cell membranes and appears to be on the surface of these cells. The protein is compared to other cell adhesion molecules from other species of cellular slime molds, and possible explanations for its inability to function in vegetative cells are discussed.

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Sep 1, 1979·European Journal of Biochemistry·K MüllerA Tsugita
Apr 5, 1978·Journal of Molecular Biology·S Bozzaro, G Gerisch
Sep 1, 1978·The Journal of Cell Biology·W R Springer, S H Barondes
May 1, 1985·Developmental Biology·W R Springer, S H Barondes
Jan 1, 1986·Journal of Cell Science. Supplement·G Gerisch
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S E Ziska, E J Henderson
Feb 1, 1986·The Journal of Cell Biology·N C BolsS H Barondes
May 1, 1987·Developmental Biology·D A KnechtW F Loomis
Apr 2, 1984·European Journal of Biochemistry·K TodaG Gerisch
Dec 1, 1980·The Journal of Cell Biology·W R Springer, S H Barondes
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·B A MurrayW F Loomis
Jan 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D K Wilcox, M Sussman
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·L M Wong, C H Siu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.