Developmentally regulated responses of human granulosa cells to insulin-like growth factors (IGFs): IGF-I and IGF-II action mediated via the type-I IGF receptor

The Journal of Clinical Endocrinology and Metabolism
D WillisS Franks

Abstract

In experimental animal models, insulin-like growth factors (IGFs) have been found to be more potent stimulators of ovarian function than insulin. In human theca cells, however, insulin, IGF-I, and IGF-II have similar effects on androgen production. The relative effects of insulin and IGFs on human granulosa cell steroidogenesis is unknown. Furthermore, it is unclear whether effects of IGF-II on steroidogenesis are mediated by the type-I or type-II IGF receptor. The effects of insulin, IGF-I, and IGF-II on human granulosa cell steroidogenesis were compared in vitro. As expected, insulin, IGF-I, and IGF-II enhanced steroidogenesis. Previously, IGF-II has been shown to enhance granulosa cell steroid production after insulin preincubation. In this study, an effect of IGF-II, independent of insulin priming, also was observed. In granulosa cell cultures from small antral follicles (< or = 13 mm), insulin and IGF-I stimulated steroid production to a similar degree, whereas IGF-II was less effective. In contrast, IGFs were more effective than insulin (IGF-I > IGF-II > insulin) in granulosa cells isolated from preovulatory follicles. IGF-I and IGF-II actions were mediated via the type-1 IGF receptor. The increased responsiveness of matu...Continue Reading

References

Nov 1, 1992·Endocrine Reviews·L C Giudice
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Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S JacobsP Cuatrecasas
Jan 1, 1995·Human Reproduction·R NahumS G Hillier

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Citations

Oct 20, 1999·Domestic Animal Endocrinology·R J ScaramuzziB K Campbell
Jan 22, 2013·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Ana Beatriz Graça DuarteJosé Ricardo de Figueiredo
Jan 5, 2013·Gynécologie, obstétrique & fertilité·N SermondadeC Sifer
Oct 27, 2004·Molecular and Cellular Endocrinology·L J SpicerD T Allen

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