Developmentally stable whole-brain volume reductions and developmentally sensitive caudate and putamen volume alterations in those with attention-deficit/hyperactivity disorder and their unaffected siblings

JAMA Psychiatry
Corina U GrevenJan K Buitelaar

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a heritable neurodevelopmental disorder. It has been linked to reductions in total brain volume and subcortical abnormalities. However, owing to heterogeneity within and between studies and limited sample sizes, findings on the neuroanatomical substrates of ADHD have shown considerable variability. Moreover, it remains unclear whether neuroanatomical alterations linked to ADHD are also present in the unaffected siblings of those with ADHD. To examine whether ADHD is linked to alterations in whole-brain and subcortical volumes and to study familial underpinnings of brain volumetric alterations in ADHD. In this cross-sectional study, we included participants from the large and carefully phenotyped Dutch NeuroIMAGE sample (collected from September 2009-December 2012) consisting of 307 participants with ADHD, 169 of their unaffected siblings, and 196 typically developing control individuals (mean age, 17.21 years; age range, 8-30 years). Whole-brain volumes (total brain and gray and white matter volumes) and volumes of subcortical regions (nucleus accumbens, amygdala, caudate nucleus, globus pallidus, hippocampus, putamen, thalamus, and brainstem) were derived from structural magne...Continue Reading

Citations

Feb 24, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L J S SchwerenP J Hoekstra
Jan 24, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Yuliya N YonchevaF Xavier Castellanos
Nov 21, 2015·Clinical Drug Investigation·Michael HussAndrea G Ludolph
Mar 5, 2016·Journal of Neural Transmission·A Marten H OnninkMartine Hoogman
Sep 21, 2015·Lancet·Anita Thapar, Miriam Cooper
Sep 18, 2015·Frontiers in Neuroscience·Marcela P Henríquez-HenríquezTilla S Worgall
Jan 1, 2015·Nature Reviews. Disease Primers·Stephen V FaraoneBarbara Franke
May 7, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Jan Malte BumbEsther Sobanski
Jul 27, 2015·Journal of the American Academy of Child and Adolescent Psychiatry·Lizanne J S SchwerenPieter J Hoekstra
Jun 9, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Timothy J SilkMark A Bellgrove
Aug 28, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Heidi A BrowneDorothy E Grice
Sep 25, 2016·Journal of the American Academy of Child and Adolescent Psychiatry·Lizanne J S SchwerenPieter J Hoekstra
Nov 27, 2016·Journal of Child Neurology·Aleksandra WyciszkiewiczKrzysztof Krawiec
Mar 10, 2017·Expert Opinion on Drug Safety·Annabeth P GroenmanPieter J Hoekstra
Feb 6, 2017·Neuroscience and Biobehavioral Reviews·Marieke KleinBarbara Franke
Oct 27, 2017·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·William M Pardridge
Mar 27, 2018·Journal of the International Neuropsychological Society : JINS·Lisa A JacobsonE Mark Mahone
Aug 4, 2018·Applied Psychophysiology and Biofeedback·Ebrahim NorouziMehran Solymani
Oct 5, 2019·Translational Psychiatry·Laura Pineda-CireraNoèlia Fernàndez-Castillo
Mar 20, 2020·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xingguang LuoChiang-Shan R Li
Jun 20, 2020·Neuropediatrics·Renate DrechslerSusanne Walitza
Oct 3, 2018·Developmental Medicine and Child Neurology·Ariadna Albajara SáenzIsabelle Massat
Jul 14, 2020·Frontiers in Neuroscience·Qiao MaoXingguang Luo
Nov 20, 2016·Movement Disorders : Official Journal of the Movement Disorder Society·Natalie J FordePieter J Hoekstra
Jun 23, 2018·Frontiers in Psychiatry·Victoria Hayman, Thomas V Fernandez
Feb 21, 2019·Psychological Medicine·Thomas WolfersAndre F Marquand
May 23, 2019·Psychological Medicine·Huey-Ling ChiangSusan Shur-Fen Gau
Oct 20, 2020·Current Directions in Psychological Science·Duncan E Astle, Sue Fletcher-Watson
Nov 30, 2019·Journal of the American Academy of Child and Adolescent Psychiatry·Hsiang-Yuan LinSusan Shur-Fen Gau
Jan 17, 2021·Brain Sciences·Ping C MamiyaMark A Stein
Oct 20, 2020·Developmental Cognitive Neuroscience·N Charlotte Onland-MoretChantal Kemner
Mar 30, 2017·Deutsches Ärzteblatt International·Tobias BanaschewskiMarcel Romanos
Nov 14, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Maria ParaskevopoulouArnt F A Schellekens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ylva OstbyKristine B Walhovd
European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
A Marten H OnninkBarbara Franke
© 2021 Meta ULC. All rights reserved