PMID: 11320331Apr 26, 2001Paper

[Developments in anti-malaria agents: chemical data, structure-activity relationships].

Annales pharmaceutiques françaises
M Debaert

Abstract

Various features of the evolution of a few antimalarial drugs including amodiaquine, dihydrofolate-reductase inhibitors, and artemisinin are described. The mechanism of action of artemisinin is detailed to explain the information of the main metabolites and drug design of certain compounds. Structure-activity and structure-neurotoxicity relations are reported. A few examples of cyclic peroxycetal synthesis are given. Finally, trends in new and novel compounds are presented.

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