Developments in intracerebral stem cell grafts

Expert Review of Neurotherapeutics
Stephanny ReyesCesar V Borlongan

Abstract

The field of stem cell therapy has emerged as a promising research area for brain repair. Optimizing the safety and efficacy of the therapy for clinical trials will require revisiting transplantation protocols. The cell delivery route stands as a key translational item that warrants careful consideration in facilitating the success of stem cell therapy in the clinic. Intracerebral administration, compared to peripheral route, requires an invasive procedure to directly implant stem cells into injured brain. Although invasive, intracerebral transplantation circumvents the prohibitive blood brain barrier in allowing grafted cells when delivered peripherally to penetrate the brain and reach the discreet damaged brain tissues. This review will highlight milestone discoveries in cell therapy for neurological disorders, with emphasis on intracerebral transplantation in relevant animal models and provide insights necessary to optimize the safety and efficacy of cell therapy for the treatment of Parkinson's disease, Huntington's disease, stroke and traumatic brain injury.

References

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Citations

Mar 22, 2016·Future Neurology·Cesar V BorlonganOlivier Detante
May 7, 2016·Expert Review of Neurotherapeutics·Hung NguyenCesario V Borlongan
Aug 9, 2016·Lancet·Cesar V Borlongan
Nov 8, 2016·Molecular Therapy : the Journal of the American Society of Gene Therapy·Cesar V Borlongan
Jun 27, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Reham S ElezabyGehanne A Awad
Feb 10, 2018·Expert Opinion on Biological Therapy·Shyam DewanCesar V Borlongan
Jul 3, 2018·Expert Review of Neurotherapeutics·Elliot G NealCesario V Borlongan

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