Developments in lung transplantation over the past decade.

European Respiratory Review : an Official Journal of the European Respiratory Society
Sophie C van der MarkMerel E Hellemons

Abstract

With an improved median survival of 6.2 years, lung transplantation has become an increasingly acceptable treatment option for end-stage lung disease. Besides survival benefit, improvement of quality of life is achieved in the vast majority of patients. Many developments have taken place in the field of lung transplantation over the past decade. Broadened indication criteria and bridging techniques for patients awaiting lung transplantation have led to increased waiting lists and changes in allocation schemes worldwide. Moreover, the use of previously unacceptable donor lungs for lung transplantation has increased, with donations from donors after cardiac death, donors with increasing age and donors with positive smoking status extending the donor pool substantially. Use of ex vivo lung perfusion further increased the number of lungs suitable for lung transplantation. Nonetheless, the use of these previously unacceptable lungs did not have detrimental effects on survival and long-term graft outcomes, and has decreased waiting list mortality. To further improve long-term outcomes, strategies have been proposed to modify chronic lung allograft dysfunction progression and minimise toxic immunosuppressive effects. This review summa...Continue Reading

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Citations

Dec 2, 2020·Science Translational Medicine·Ankit BharatG R Scott Budinger
Jun 15, 2021·Frontiers in Immunology·Katherine A YoungLaurie D Snyder
Aug 6, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Siddhartha G Kapnadak, Ganesh Raghu
Aug 31, 2021·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Om Prakash Yadava
Aug 13, 2021·American Journal of Respiratory and Critical Care Medicine·Dmitry RozenbergChung-Wai Chow

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