Developments in the management of autosomal dominant polycystic kidney disease.

Therapeutics and Clinical Risk Management
Amirali MasoumiRobert W Schrier

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent life- threatening, hereditary disease. ADPKD is more common than sickle cell anemia, cystic fibrosis, muscular dystrophy, hemophilia, Down's syndrome, and Huntington's disease combined. ADPKD is a multisystemic disorder characterized by the progressive development of renal cysts and marked renal enlargement. Structural and functional renal deterioration occurs in ADPKD patients and is the fourth leading cause of end-stage renal disease (ESRD) in adults. Aside from the renal manifestations, extrarenal structural abnormalities, such as liver cysts, cardiovascular abnormalities, and intracranial aneurysms may lead to morbidity and mortality. Recent studies have identified prognostic factors for progressive renal impairment including gender, race, age, proteinuria, hematuria, hypertension and increased left ventricular mass index (LVMI). Early diagnosis and better understanding of the pathophysiology of the disease provides the opportunity to aggressivly treat hypertension with renin-angiotensin-aldosterone system inhibitors and thereby potentially reduce LVMI, prevent cardiovascular morbidity and mortality and slow progression of the renal disease.

References

Jan 1, 1976·Urology·L RavichJ Drabkin
Sep 24, 1992·The New England Journal of Medicine·A B ChapmanW D Kaehny
Dec 1, 1990·Kidney International·P A GabowR W Schrier
Jul 1, 1990·Mayo Clinic Proceedings·A TelentiR R Hattery
Jan 1, 1990·Gastrointestinal Radiology·S K Wan, D L Cochlin
Jun 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A GabowG T Everson
Sep 1, 1990·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A B ChapmanP A Gabow
Jan 25, 1986·British Medical Journal·J W Hetherington, N H Philp
Nov 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G T EversonP Gabow
Oct 6, 1988·The New England Journal of Medicine·K F HossackP A Gabow
Jan 1, 1987·Archives of Disease in Childhood·L S TaitzG M Steiner
Aug 1, 1985·AJR. American Journal of Roentgenology·E LevineJ J Grantham
Dec 1, 1974·The Journal of Pediatrics·C Kaye, P R Lewy
Sep 1, 1971·Journal of Medical Genetics·H Blyth, B G Ockenden
May 1, 1984·Annals of Internal Medicine·C V LeierC F Wooley
May 1, 1980·The American Journal of Medicine·J MilutinovicJ I Bryant
Aug 1, 1994·Seminars in Liver Disease·I D D'AgataL M Guay-Woodford
Apr 1, 1994·Kidney International·D ChauveauJ P Grünfeld
Oct 1, 1993·Urology·G A AndersonR K Lawson
Oct 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V E TorresJ W Segura
Oct 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A B ChapmanP A Gabow
Feb 1, 1994·Radiology·E vanSonnenbergP L Cooperberg
Jun 1, 1993·Journal of the American Society of Nephrology : JASN·G M FickP A Gabow
Mar 1, 1993·Cardiovascular and Interventional Radiology·G SimonettiA Orlacchio
Jan 2, 1997·The New England Journal of Medicine·W I Schievink
Jan 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·D ChauveauJ Belghiti
Dec 1, 1996·The British Journal of Surgery·M KabbejJ Belghiti
Jan 1, 1996·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·J DmitrewskiJ A Buckels
Nov 15, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R ShersthaG T Everson

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Citations

Aug 23, 2002·Trends in Cell Biology·Mary SteinTamara Roitbak
Sep 23, 1998·Molecular Medicine Today·J Young, S Povey
Sep 7, 2013·Journal of the American Society of Nephrology : JASN·Benjamin S FreedmanJoseph V Bonventre
Jun 10, 2010·Southern Medical Journal·Tanmay S Panchabhai, George R Aronoff
Nov 21, 2013·Stroke; a Journal of Cerebral Circulation·Ankit SakhujaSankar D Navaneethan
Dec 10, 2014·Current Opinion in Pediatrics·Yu Leng Phua, Jacqueline Ho
Nov 20, 2012·Journal of Endourology·Melissa MillarR Sherburne Figenshau
Feb 19, 2011·Communicative & Integrative Biology·Eva SammelsHumbert De Smedt
Mar 17, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Guangfu JiaFrank Park
Dec 15, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Brian J SirokyJohn J Bissler
Jul 16, 2011·The American Journal of the Medical Sciences·Tsukasa NakamuraHikaru Koide

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Methods Mentioned

BETA
hormone replacement therapy
imaging techniques

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