Developments of mass spectrometry-based technologies for effective drug development linked with clinical proteomes

Drug Metabolism and Pharmacokinetics
Noboru NakayamaToshihide Nishimura

Abstract

A strong demand in drug discovery and development today is to overcome "Big Gaps" encountered by differences in species and races, to accelerate effective developments in cost and time, and to meet medical needs. Moreover, drugs of various types have emerged which cover middle-size molecules and polymers rather than conventional small molecules. Upon those challenges, mass spectrometry (MS)-based technologies, which will be described in this paper, will play an increasingly important role, among which the liquid chromatography-tandem mass spectrometry (LC/MS/MS) platform will be powerful as rapid and molecule-based analysis more than ever. nanoPore Optical Interferometry (nPOI) newly introduced can detect even weak interactions in protein-protein and protein-compound, and can be connected directly to LC/MS/MS for identification of binding molecular species, which will be quite useful for affinity ranking and high-throughput interaction screening. Imaging MS provides the molecular information and spatial distribution of targeted molecules within a tissue specimen. MS-based clinical proteomics utilizing clinical specimens and empowered by advanced bioinformatics can attain both key protein-protein interaction (PPI) networks with ...Continue Reading

References

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Aug 22, 2013·Proceedings of the National Academy of Sciences of the United States of America·Stephen Ornes
Jan 31, 2015·Clinical and Translational Medicine·Toshihide NishimuraGyörgy Marko-Varga
Jan 31, 2015·The New England Journal of Medicine·Francis S Collins, Harold Varmus
May 16, 2015·Analytical Chemistry·Vladimir GorshkovFrank Kjeldsen
Jul 15, 2015·Clinical and Translational Medicine·Yasufumi KatoHarubumi Kato
Jul 23, 2015·Archives of Pharmacal Research·Ho Jeong KwonGyörgy Marko-Varga

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Citations

Feb 15, 2018·Rapid Communications in Mass Spectrometry : RCM·Naoko ObiTakeshi Kawamura
Dec 21, 2017·Expert Review of Proteomics·Heng Wee TanAndy T Y Lau

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