Developments towards an artificial kidney

Expert Review of Medical Devices
William H Fissell

Abstract

This article reviews the present state of renal failure and its treatment in the industrialized world. Novel and experimental therapies for the treatment of renal failure are covered, with special emphasis on a hybrid bioartificial kidney currently undergoing clinical trials in the USA. Preclinical data, results from human trials and work on miniaturization of the bioartificial kidney for implantation are presented. Research on microfluidics and nanotechnology applied to dialysis is ongoing in many academic centers, and several promising approaches are discussed. After 10 years of incremental improvements in end-stage renal disease care, several revolutionary technologies are on the horizon and approaching the marketplace.

References

Dec 23, 1975·Anatomy and Embryology·B KaisslingW Kriz
Jun 9, 1998·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·S M MacKayH D Humes
May 20, 1999·Nature Biotechnology·H D HumesW F Weitzel
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·V RuotsalainenK Tryggvason
Feb 13, 2001·Kidney International. Supplement·M GirndtH Köhler
Mar 10, 2001·The New England Journal of Medicine·G R BernardUNKNOWN Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Apr 30, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H David HumesJorge M Gutierrez
Aug 21, 2002·JAMA : the Journal of the American Medical Association·Djillali AnnaneEric Bellissant
Dec 20, 2002·The New England Journal of Medicine·Garabed EknoyanUNKNOWN Hemodialysis (HEMO) Study Group
Jan 23, 2003·Journal of the American Society of Nephrology : JASN·William H FissellH David Humes
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Oliver Smithies
Oct 8, 2003·Critical Care Medicine·H David HumesWilliam H Fissell
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Tapani SalonenAmos Pasternack
Jan 21, 2004·Blood Purification·Edward F LeonardMona U Larsen
Jul 21, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Daniel E WeinerMark J Sarnak
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Yunxia TaoCharles L Edelstein
Dec 9, 2004·American Journal of Physiology. Renal Physiology·Anna BjörnsonJenny Sörensson
Mar 10, 2005·The Medical Clinics of North America·Panagiotis T Vlagopoulos, Mark J Sarnak
May 7, 2005·Contributions to Nephrology·Victor GuraHans-Dietrich Polaschegg
May 7, 2005·Contributions to Nephrology·Edward F LeonardNicholas G Vitale

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Citations

Jun 16, 2007·Nature Reviews. Immunology·Yong-Guang Yang, Megan Sykes
Sep 6, 2007·Blood Purification·Jeroen P KoomanKarel M L Leunissen
Jul 30, 2010·American Journal of Physiology. Renal Physiology·Joseph GroszekWilliam H Fissell
Jul 9, 2008·The International Journal of Artificial Organs·E WeinbergJ Borenstein

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