Device closure of paravalvular defects following transcatheter aortic valve replacement with the Edwards Sapien valve

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Brian K WhisenantSteve Horton

Abstract

Paravalvular aortic insufficiency (AI) is observed in the majority of patients undergoing transcatheter aortic valve replacement (TAVR). While paravalvular AI is most commonly modest following TAVR, moderate or severe AI was seen in 10.5% and 6.8% of the PARTNER inoperable and high-risk cohorts at 1 year and has been reportedly associated with dyspnea and diminished survival. We report two cases of transcatheter heart valve (THV) associated paravalvular defects closed using catheter delivered devices. Both patients derived hemodynamic and symptomatic improvement from device closure. Additional research is warranted to define the adverse consequences of THV associated AI, indications for treatment, and risks associated with device closure of these defects.

References

Jul 1, 2009·Circulation·Karen K Stout, Edward D Verrier
Jul 25, 2009·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Josep Rodés-CabauDaniel Doyle
Oct 22, 2010·The New England Journal of Medicine·Martin B LeonUNKNOWN PARTNER Trial Investigators
Mar 15, 2011·Heart·Mohamed Abdel-WahabUNKNOWN German transcatheter aortic valve interventions registry investigators
Apr 8, 2011·International Journal of Cardiology·Antonio J Muñoz-GarcíaEduardo de Teresa-Galván
Jun 7, 2011·The New England Journal of Medicine·Craig R SmithUNKNOWN PARTNER Trial Investigators

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Citations

Sep 18, 2013·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Jan-Malte SinningEberhard Grube
Oct 17, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Petra Poliacikova, David Hildick-Smith
Sep 17, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sameer GafoorHorst Sievert
Feb 11, 2015·Cardiovascular Intervention and Therapeutics·James CockburnDavid Hildick-Smith
Sep 17, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ted FeldmanSteven Smart
Jan 22, 2014·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Creighton W Don, Larry S Dean
Mar 19, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Nikos Werner, Jan-Malte Sinning
May 7, 2013·Journal of the American College of Cardiology·Jan-Malte SinningNikos Werner
May 25, 2016·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Abhijeet DhobleRaj Makkar
Oct 28, 2016·Clinical Cardiology·Tomo AndoUNKNOWN ALICE (All-Literature Investigation of Cardiovascular Evidence) Group
Jul 16, 2014·Expert Review of Cardiovascular Therapy·Mohamed El-MawardyGert Richardt
Mar 26, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Paul Sorajja

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