Device profile of the Resolute Onyx Zotarolimus eluting coronary stent system for the treatment of coronary artery disease: overview of its safety and efficacy

Expert Review of Medical Devices
Moritz BlumRoxana Mehran

Abstract

Introduction: The increasing complexity of patients undergoing percutaneous coronary intervention (PCI) regarding both coronary anatomy and comorbidities requires dedicated devices. The Resolute Onyx (R-Onyx, Medtronic, CA, USA) stent is a novel durable polymer zotarolimus-eluting stent (ZES) promising better deliverability, increased radiopacity and lower thrombogenicity.Areas covered: In this review, we discuss device features, preclinical evidence, and clinical studies including patients treated with R-Onyx. The BIONYX and Onyx ONE studies were two major landmark trials demonstrating non-inferiority of R-Onyx as compared to other latest generation devices. We also elaborate on alternative innovations in drug-eluting stent (DES) technology and how R-Onyx fits into this field.Expert opinion: R-Onyx is designed to address the challenges of contemporary PCI, but evidence on its clinical performance is largely derived from studies on older generation devices from the ZES family. Nonetheless, all clinical studies on R-Onyx consistently show excellent outcomes, with particularly low rates of stent thrombosis, making it a promising candidate for short dual antiplatelet regimens. In addition, R-Onyx is available with a wide range of ...Continue Reading

References

Apr 4, 2006·Advanced Drug Delivery Reviews·Sandra E BurkeLewis B Schwartz
Feb 14, 2007·The New England Journal of Medicine·Adnan KastratiAlbert Schömig
May 6, 2010·Circulation. Cardiovascular Interventions·Juan F GranadaRenu Virmani
Aug 2, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Stephen Wai Luen LeeKelvin K W Chan
Nov 29, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Louis A CannonMarco A Costa
Dec 6, 2011·JACC. Cardiovascular Interventions·John A OrmistonMark W I Webster
Oct 30, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·James A ShandSimon J Walsh
Feb 28, 2015·Journal of the American College of Cardiology·Marco ValgimigliUNKNOWN ZEUS Investigators
Sep 1, 2015·Journal of the American College of Cardiology·Philippe GénéreuxGregg W Stone
Oct 16, 2015·The New England Journal of Medicine·Philip UrbanUNKNOWN LEADERS FREE Investigators
Jul 12, 2016·International Journal of Cardiology·Jaryl NgPhilip Wong
Nov 21, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Manish A ParikhAjay Kirtane
Dec 6, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Liefke C van der HeijdenClemens von Birgelen
Jan 23, 2017·JACC. Cardiovascular Interventions·Robert W YehLaura Mauri
Apr 15, 2017·Circulation Research·Yohei SotomiPatrick W Serruys
Aug 2, 2017·The Journal of International Medical Research·Chor Cheung TamHung Fat Tse
Aug 28, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Giulio G StefaniniAdnan Kastrati
Sep 25, 2017·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Matthew J PriceRoxana Mehran
Nov 5, 2017·Journal of the American College of Cardiology·Dean J KereiakesUNKNOWN ABSORB III Investigators
Feb 1, 2019·Circulation·Emelia J BenjaminUNKNOWN American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee
Sep 10, 2019·Postępy w kardiologii interwencyjnej = Advances in interventional cardiology·Tomasz RolederWojciech Wojakowski
Feb 13, 2020·The New England Journal of Medicine·Stephan WindeckerUNKNOWN ONYX ONE Investigators

❮ Previous
Next ❯

Citations

May 19, 2020·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Mauro Chiarito, Roxana Mehran
Apr 18, 2021·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Anne CornelissenAloke Finn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.