Dexamethasone Administration During Late Gestation Has No Major Impact on Lipid Metabolism, but Reduces Newborn Survival Rate in Wistar Rats

Frontiers in Physiology
Katia MottaAlex Rafacho

Abstract

A rise in plasma triacylglycerol levels is a common physiological occurrence during late gestation and excess of glucocorticoids (GCs) has been shown to impair lipid metabolism. Based on those observations, we investigated whether the administration of dexamethasone during the late gestational period could exacerbate this pregnancy associated hypertriacylglycerolemia in rats. For this, female Wistar rats were treated with dexamethasone (0.2 mg/kg of body mass in the drinking water on days 14-19 of pregnancy; DP group) or equivalent days in the virgin rats (DV group). Untreated pregnant rats (control pregnant group) and age-matched virgin rats (control virgin group) were used as controls. Functional, biochemical, and molecular analyses were carried out after treatment with GC and in the control groups. Euthanasia was performed on day 20 of pregnancy. The metabolic parameters of the mothers (dams) at the time of weaning and 6 months later, as well as newborn survival, were evaluated. We observed that neither dexamethasone nor pregnancy affected blood glucose or glucose tolerance. Hypertriacylglycerolemia associated with lipid intolerance or reduced hepatic triacylglycerol clearance was observed during the late gestational period....Continue Reading

References

Jan 1, 1977·Otolaryngologia polska. The Polish otolaryngology·Z BochenekK Stelmaszek
Nov 1, 1988·Metabolism: Clinical and Experimental·W H Ettinger, W R Hazzard
Apr 1, 1987·The Journal of Clinical Endocrinology and Metabolism·G DesoyeG M Kostner
Mar 1, 1970·Endocrinology·Y AmenomoriJ Meites
Jan 1, 1981·Biology of the Neonate·J Argiles, E Herrera
May 15, 1981·The Biochemical Journal·L AgiusD H Williamson
Jun 1, 1997·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R L Sorenson, T C Brelje
Dec 17, 1997·The Journal of Clinical Endocrinology and Metabolism·R H Knopp, X Zhu
May 8, 1998·The Proceedings of the Nutrition Society·A L FowdenA J Forhead
Sep 14, 2001·Metabolism: Clinical and Experimental·F Caldefie-ChézetM Vasson
May 3, 2005·Current Opinion in Allergy and Clinical Immunology·Jennifer Altamura Namazy, Michael Schatz
Jul 5, 2005·Journal of Lipid Research·John S MillarJeffrey T Billheimer
Sep 27, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nicholas D OakesBengt Ljung
Jan 13, 2006·Neurobiology of Aging·Mia EmgårdLaura Calzà
Nov 5, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Guy Van VlietE Martin Ritzén
Jun 17, 2010·Current Pharmaceutical Design·Amalia GastaldelliSilvia Maffei
Aug 26, 2011·Metabolism: Clinical and Experimental·Ashley J PeckettMichael C Riddell
Oct 25, 2011·PloS One·Laura L GathercoleJeremy W Tomlinson
Aug 31, 2012·The Journal of Clinical Endocrinology and Metabolism·Tanja G M VrijkotteMarcel B Twickler
Sep 14, 2012·Clinical and Experimental Pharmacology & Physiology·Reetu R SinghKaren M Moritz
Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Batbayar Khulan, Amanda J Drake
Sep 24, 2013·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Everson A NunesAlex Rafacho
Nov 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Patrícia R GomesSilvana Bordin
Apr 12, 2014·Current Pharmaceutical Biotechnology·Emilio Herrera, Henar Ortega-Senovilla
Oct 1, 2014·The Journal of Steroid Biochemistry and Molecular Biology·Katia MottaAlex Rafacho
Oct 2, 2014·Canadian Journal of Physiology and Pharmacology·Cristiane dos SantosAlex Rafacho
Feb 3, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·D R FariasG Kac
Sep 20, 2015·The Journal of Steroid Biochemistry and Molecular Biology·André Otávio Peres ProtzekAntonio Carlos Boschero
Feb 20, 2016·Endocrinology and Metabolism Clinics of North America·Robert WildDon Wilson
Apr 7, 2016·Journal of Perinatal Medicine·Serdar BaşaranoğluTalip Gül
Jun 7, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Francielle Garghetti BattistonAlex Rafacho

❮ Previous
Next ❯

Citations

Apr 8, 2020·Canadian Journal of Physiology and Pharmacology·Olufunto O Badmus, Lawrence A Olatunji
Jan 29, 2019·Frontiers in Neuroscience·Felipe Azevedo GomesAlex Rafacho
Feb 27, 2021·Journal of Veterinary Internal Medicine·Leslie F WeaverJared D Taylor
Jun 21, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Flaviano LorenzonFernanda B Lima

❮ Previous
Next ❯

Methods Mentioned

BETA
lavage
PCRs
PCR
AlphaLISA
electrophoresis

Software Mentioned

ZenLite
GraphPad QuickCalcs
GraphPad
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.