PMID: 9185085Jun 1, 1997Paper

Dexamethasone and flumethasone residues in milk of intramuscularly dosed cows

Journal of Veterinary Pharmacology and Therapeutics
J RedingH Naegeli

Abstract

A field study was performed to assess the level of drug residues in milk after therapeutic application of highly potent synthetic glucocorticoids. Dexamethasone was tested either as a crystalline suspension or as a combination of sodium phosphate and phenylpropionate esters. Intramuscular injection of these preparations in lactating dairy cows (60 micrograms dexamethasone/kg body wt) yielded drug residues in milk of up to 8.4 ng/mL 12 h after treatment. These dexamethasone residues fell to below 1.0 ng/mL within 3 days after treatment. Intramuscular injection of an aqueous flumethasone preparation (13.5 micrograms/kg body wt) produced drug residues in milk in the range of 0.7-1.2 ng/mL 12 h after treatment, whereas flumethasone was below the detection limit of 0.23 ng/mL 2 days after administration. These results indicate that toxicologically significant residues may arise transiently in the milk during the first 2-3 days after intramuscular injection of synthetic glucocorticoids. Urine from the same animals contained 5- to 50-fold higher glucocorticoid concentrations than the corresponding milk samples. Thus, urine analysis appears to be an effective method to monitor the use of synthetic glucocorticoids in food producing anim...Continue Reading

References

May 4, 1991·The Veterinary Record·H PhilippJ F Quirke
Oct 1, 1982·Journal of Dairy Science·D TainturierP L Toutain
Jan 1, 1994·Rheumatology International·H TanakaI Makino
Jan 1, 1986·Journal of Pharmaceutical and Biomedical Analysis·H DerendorfH Möllmann

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Citations

Dec 30, 2015·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Konstanze SchellerJohannes Schubert
Sep 28, 2001·Journal of Dairy Science·S M MacielL J Spicer
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Aneliya Milanova HaritovaJohanna Fink-Gremmels

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